Protein Alignment MCPH1 and BRCA1

DIOPT Version :10

• Sequence 1: NP_001163123.1
• Gene: MCPH1 / 36272
• FlyBaseID: FBgn0260959
• Length: 1028
• Species: Drosophila melanogaster
• Sequence 2: NP_193839.4
• Gene: BRCA1 / 827854
• AraportID: AT4G21070
• Length: 941
• Species: Arabidopsis thaliana
• Alignment Length: 1152
• Identity: 221/1152 - (19%)
• Similarity: 381/1152 - (33%)
• Gaps: 424/1152 - (36%)

  Fly    16 YGSVVASS-------AAAAKKTAASST----RRPLH----------DSNLGDFRSKAAAPSPK-S 58
            |.|.|:.|       |...|.....:|    :.|.|          ||.:..:::...|...| .
plant    23 YNSAVSLSCNHVFCNACIVKSMKMDATCPVCKIPYHRREIRGAPHMDSLVSIYKNMEDASGIKLF 87

  Fly    59 LSQ---APAD-DQAARDRLMLKPALAVSKAISQHRSEFHQDENEAGA-EGSAAK----------- 107
            :||   :|:| ::..||       .:|.||         .|:|..|: :|.|:|
plant    88 VSQNNPSPSDKEKQVRD-------ASVEKA---------SDKNRQGSRKGRASKRNEYGKTKEID 136

  Fly   108 ---PDPPIGAATPTRQEGHWARLQQDLNSPNAALRLRAIRALKSPTKSAYNTFDVP--LAEQSII 167
               |.|.:  ..|:.|.....:|.|:|::          .:|..||:|. .|.:.|  ..|.::|
plant   137 VDAPGPIV--MKPSSQTKKRVQLLQNLSA----------ESLTKPTESV-ETAEKPKDYTENTVI 188

  Fly   168 TMEERNPQEPPSLPELLKD--IVVYVEVRTGND--NRSEGVKSIIAKMGAQVKDRLTRTTTHVVF 228
            .::|.        |.|.|:  :..:..:|..:|  |.|:..:|
plant   189 RLDEH--------PSLNKEGNLSPFFWLRDEDDGENSSQRTES---------------------- 223

  Fly   229 KDGLLSTYKKATEWNIPVVSILWIEACKVQLKICDPKQFP----ISNIRMYEY------PELFGK 283
             |.||.|    |..|:|..|.|.....:...|. |.:|.|    :.:..|:|:      ||:...
plant   224 -DQLLGT----TPVNVPSFSDLMDSDHESPSKE-DEQQKPNPGDMFDSEMFEWTQRPCSPEILPS 282

  Fly   284 MPRVKFMQPDS-ELNQRPRKRQGTPTSS-KDNEPGSTNKRAQTGTPTTTTPKNDISRFFRAINHN 346
            ..:.|.:..|. :|.|:...:....:|. |:.:.||.              :|.::|  |:|.
plant   283 PVKAKVLGRDEIDLTQKKLPKVKVASSKCKNRKAGSA--------------RNTVAR--RSIG-- 329

  Fly   347 KPSDDEAIESPATKLLNRISSGCYTPLPAGGTPQLMGTNGSGDAVAQKVQAQKSLQFGEQTDSNT 411
             .|.::.:||.|...::.....             .||  ||..:...|          .||.|.
plant   330 -VSQEDNMESSAAATISEQQDS-------------RGT--SGTIIRNDV----------NTDENV 368

  Fly   412 PQAKPSSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEISSPAATDTRMTRRRSSLLTSTVIHEAD 476
             :||.::.|:               .::||.:|.: .:|:.|.......|:|||:.:|.....|.
plant   369 -KAKRATRSK---------------AQSTRVQSDL-NVSNEADGKQGTKRKRSSIKSSPAHPIAG 416

  Fly   477 PTQTAVAEPRMTRRRSSLLGIAKQAEETAQRQTIQPITEELAPVEENRNSIIMAETNIINNTNCL 541
            |.:.::.        :.::|...|.:......| .|  |:.:|.|
plant   417 PNELSLG--------TEIVGKGDQDQAHGPSDT-HP--EKRSPTE-------------------- 450

  Fly   542 EQSIEITAVEAEASFKADRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRARQSLSN-VTT 605
                       :.|.|...|.:..:|.|.|:|...::..::..|:|....::.:|.|...| :.|
plant   451 -----------KPSLKKRGRKSNASSSLKDLSGKTQKKTSEKKLKLDSHMISSKATQPHGNGILT 504

  Fly   606 QTSFLDVEQQVTPLFSSTRLPTGQTTGNRRRTIFNMD--MDV------INES-------IERMNQ 655
            .......::|             .:..||:.|:...|  |.|      ||:|       :.|.|.
plant   505 AGLNQGGDKQ-------------DSRNNRKSTVGKDDHTMQVIEKCSTINKSSSGGSAHLRRCNG 556

  Fly   656 S--HRMSLALANKAE----LGESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVISPAMSNRKS 714
            |  .:.:.|....:|    .||....:..||..|:            ||...:|:
plant   557 SLTKKFTCAFCQCSEDTEASGEMTHYYRGEPVSAD------------FNGGSKVI---------- 599

  Fly   715 RLSITGSGSSSSVQKRRRSLA-----------------TPAKSSSSELCATTPLSKAVTNKEAEK 762
                       .|.|.....|                 |.::..|...|.....:....||..
plant   600 -----------HVHKNCAEWAPNVYFNDLTIVNLDVELTRSRRISCSCCGLKGAALGCYNKSC-- 651

  Fly   763 SKSNTEISEASLDAVPE-----------------VKKSTSNAGEENEK------------PK--- 795
             |::..::.|.|  :||                 :|.....|..::.|            ||
plant   652 -KNSFHVTCAKL--IPECRWDNVKFVMLCPLDASIKLPCEEANSKDRKCKRTPKEPLHSQPKQVS 713

  Fly   796 GKSRTRIRTLVHTNMHQEQINVIRKAL------------------RKLRGMRLDPTVTQHTTHLV 842
            ||:..|       .:|.:|.:...|.|                  .:|.|:.:........||::
plant   714 GKANIR-------ELHIKQFHGFSKKLVLSCSGLTVEEKTVIAEFAELSGVTISKNWDSTVTHVI 771

  Fly   843 -SLEP----RRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYELTRFSRAIEICRTERQAF 902
             |:..    :|||..:..::.|.||::..|:.|.::..|:::|||||:|.....|.    |....
plant   772 ASINENGACKRTLKFMMAILEGKWILTIDWIKACMKNTKYVSEEPYEITMDVHGIR----EGPYL 832

  Fly   903 G----VHYQCELFRFMEPFYVSSLCRPVQFNNMKELLLLGGA----------------------- 940
            |    :..:.:||..:: ||:...........:::|::..|.
plant   833 GRQRALKKKPKLFTGLK-FYIMGDFELAYKGYLQDLIVAAGGTILRRRPVSSDDNEASTIVVFSV 896

  Fly   941 ------TLTENRFKAKYIIGDKR-RAEDDRVYLDPYWVLDSITNMQI 980
                  |||:.|..|:.:....| ||....      ||||||...||
plant   897 EPSKKKTLTQRRSDAEALAKSARARAASSS------WVLDSIAGCQI 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	BRCT_microcephalin_rpt1	186..260	CDD:349348	14/77 (18%)
		BRCT_microcephalin_rpt2	803..878	CDD:349368	18/97 (19%)
		BRCT_microcephalin_rpt3	905..980	CDD:349382	20/104 (19%)
BRCA1	NP_193839.4	RING-HC_AtBRCA1-like	10..63	CDD:438509	9/39 (23%)
		rad18	14..>243	CDD:273165	61/283 (22%)
		ePHD	596..678	CDD:277046	14/107 (13%)
		BRCT_Bard1_rpt1	733..812	CDD:349366	15/78 (19%)
		BRCT	844..933	CDD:469589	19/95 (20%)