DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCPH1 and MCPH1

DIOPT Version :9

Sequence 1:	NP_001163123.1	Gene:	MCPH1 / 36272	FlyBaseID:	FBgn0260959	Length:	1028	Species:	Drosophila melanogaster
Sequence 2:	XP_016869318.1	Gene:	MCPH1 / 79648	HGNCID:	6954	Length:	877	Species:	Homo sapiens

Alignment Length:	921	Identity:	221/921 - (23%)
Similarity:	367/921 - (39%)	Gaps:	231/921 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 LLKDIVVYVEV--RTGNDNRSEGVKSIIAKMGAQVKDRLTRTTTHVVFKDGLLSTYKKATEWNIP 245
            :|||:|.||||  ..|.:|.|:...:.:..|||:|.....:..|||:||||..||:.||.:..:.
Human     5 ILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTWDKAQKRGVK 69

  Fly   246 VVSILWIEACKVQLKICDPKQFPISNIRMYEYPELFGKMPRVKFMQPDS------ELNQRPRKR- 303
            :||:||:|.|:......|...||.:|  |.|:.....|..| |.|||..      |.::|.:|:
Human    70 LVSVLWVEKCRTAGAHIDESLFPAAN--MNEHLSSLIKKKR-KCMQPKDFNFKTPENDKRFQKKF 131

  Fly   304 -------QGTPTSSKDNEP-------GSTNKRAQTGTPTTTTPKNDISRFFRAINHNK------- 347
                   |...|:..|:.|       ||.     ..|||........|...:.:...|
Human   132 EKMAKELQRQKTNLDDDVPILLFESNGSL-----IYTPTIEINSRHHSAMEKRLQEMKEKRENLS 191

  Fly   348 PSDDEAI----ESPATKLLNRISSGCYTPLP------------AGGT----PQLMGTNGSGDAVA 392
            |:..:.|    ::|:..|       |..||.            |||.    ..|.|.:|.|:
Human   192 PTSSQMIQQSHDNPSNSL-------CEAPLNISRDTLCSDEYFAGGLHSSFDDLCGNSGCGN--- 246

  Fly   393 QKVQAQKSLQFGEQTD-------------SNTPQAKPSST----SRPRR--STVDPPPVMTPPVR 438
                .::.|: |...|             :|...:.||.|    |.|::  |.:....:
Human   247 ----QERKLE-GSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEI------ 300

  Fly   439 TTRRRSCVAEISSP----AATDTRMT----RRRSSLLTST----VIHEADPTQTAVAEPRMT--- 488
             ..:|:...::.:|    ||..::.|    .|.|..|:||    :|| :.|..::|...|::
Human   301 -NLQRNIAGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIH-SRPRSSSVKRKRVSHGS 363

  Fly   489 ---------RRRSSLLGIAKQAEETAQRQTIQPITEELAPVEENRNSIIMAETNIINNTNCLEQS 544
                     |:||:             |::|.|           |..:..:|..:        |.
Human   364 HSPPKEKCKRKRST-------------RRSIMP-----------RLQLCRSEDRL--------QH 396

  Fly   545 IEITAVEA----EAS----FKADRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRARQSL- 600
            :...|:||    |:|    |..|.....|:..|     |....:..|..:|...:|:.:.|.|:
Human   397 VAGPALEALSCGESSYDDYFSPDNLKERYSENL-----PPESQLPSSPAQLSCRSLSKKERTSIF 456

  Fly   601 -----SNVTTQTSFLDVEQQVTPLFSSTRLPTGQTTGN-RRRTIFNMDMDVINESIERMNQSHRM 659
                 |.|..:|..:|:..     |::..:.:.:.||| ..|...:.......|::....|
Human   457 EMSDFSCVGKKTRTVDITN-----FTAKTISSPRKTGNGEGRATSSCVTSAPEEALRCCRQ---- 512

  Fly   660 SLALANKAEL-----GESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVISPAMSNRKSRLSIT 719
                |.|.:.     |.|..:.:...|:.              :.:|...:..::...|..:.:.
Human   513 ----AGKEDACPEGNGFSYTIEDPALPKG--------------HDDDLTPLEGSLEEMKEAVGLK 559

  Fly   720 GSGSSSSVQKRRRSLATPAKSSSSELCATTPLSKAVTNKEAE----------KSK-SNTEISEAS 773
            .:.:..:..|...|....|: |..|.|.....:...:.:|.|          |:: :..::.:.|
Human   560 STQNKGTTSKISNSSEGEAQ-SEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNRPTRHDVLDDS 623

  Fly   774 LDAVPEVKKSTSNAGEENEKPKGKSRTRIRTLVHTNMHQEQINVIRKALRKLRGMRLDPTVTQHT 838
            .|...::.|.     .|..|..|:.:...||||.|:|..|:.||:.:.:.||:|..:.|.|.:.|
Human   624 CDGFKDLIKP-----HEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETT 683

  Fly   839 THLVSLEPRRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYELTRFSRAIEICRTERQAFG 903
            ||::|.:|.||||:|.|:.||.|::||.|||.|:..|.||:|||:||:....|..:||:|.....
Human   684 THVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELSHHFPAAPLCRSECHLSA 748

  Fly   904 VHYQCELFRFMEPFYVSSLCRPVQFNNMKELLLLGGATLTENRFKAKYIIG---DKRRAEDDRVY 965
            ..|:..||......:||....| ....:.||:.|.|..:::...:|..:||   .|::|...  |
Human   749 GPYRGTLFADQPAMFVSPASSP-PVAKLCELVHLCGGRVSQVPRQASIVIGPYSGKKKATVK--Y 810

  Fly   966 LDPYWVLDSIT 976
            |...||||.::
Human   811 LSEKWVLDGVS 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	PTCB-BRCT	187..251	CDD:289507	25/65 (38%)
MCPH1	NP_001163123.1	BRCT	812..873	CDD:237994	28/60 (47%)
MCPH1	XP_016869318.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141027
Domainoid	1	1.000	53	1.000	Domainoid score	I11407
eggNOG	1	0.900	-	-		E1_KOG4362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3806
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1589580at2759
OrthoFinder	1	1.000	-	-		FOG0006938
OrthoInspector	1	1.000	-	-		oto89704
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14625
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4865
SonicParanoid	1	1.000	-	-		X5030
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.020