DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCPH1 and mcph1

DIOPT Version :9

Sequence 1:	NP_001163123.1	Gene:	MCPH1 / 36272	FlyBaseID:	FBgn0260959	Length:	1028	Species:	Drosophila melanogaster
Sequence 2:	XP_005157146.1	Gene:	mcph1 / 678616	ZFINID:	ZDB-GENE-060421-6122	Length:	728	Species:	Danio rerio

Alignment Length:	858	Identity:	210/858 - (24%)
Similarity:	349/858 - (40%)	Gaps:	194/858 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 LKDIVVYVEVRTGN--DNRSEGVKSIIAKMGAQVKDRLTRTTTHVVFKDGLLSTYKKATEWNIPV 246
            |||:|.||:|.:.:  ::.|:.....:..|||||...|.:..|||:||.|..||:|||.:..:.:
Zfish    13 LKDVVAYVDVWSASRMEDYSDPFIEQLQDMGAQVSKTLNKQVTHVIFKHGRPSTWKKALKIGVKI 77

  Fly   247 VSILWIEACKVQLKICDPKQFPISNIRMYEYPELFGKMPRVKFMQPDSELNQRPRKRQGTPTSSK 311
            ||:.|:..||.            :|..:.|  |||                         |..::
Zfish    78 VSVHWVARCKE------------TNQHINE--ELF-------------------------PAQNE 103

  Fly   312 DNEPGSTNKRAQTGTPTTTTPKNDISRFFRAINHNKPSDDEAIESPATKLLNRISSGCYTPLPAG 376
            :::...||||    |.....|:|        |....|.:|..::....|::..:...  :|:.:.
Zfish   104 ESKRHLTNKR----THCCMQPRN--------IPIKTPENDRRLKRKIDKMMEGLVPS--SPIVSD 154

  Fly   377 GTPQLMGTNGS---------GDAVAQKVQAQKSLQFGEQTDSNTPQAKPSSTSRPRRSTVDPPPV 432
            .:|.::.....         .|::||::   |.::.|.:..|.|...|....|..     ||.|
Zfish   155 TSPFIIDEERGIVYSPSLKRSDSMAQRL---KEMKAGREHLSPTASQKQDIGSEH-----DPSP- 210

  Fly   433 MTPPVRTTRRRSCVAEISSPAATDTRMTRRRSSLLTSTVIHEADPTQTAVAEPRMTR-RRSSLLG 496
                               ||:|       ..|.|........||...:..:....| .|..|..
Zfish   211 -------------------PAST-------ALSFLQQLEEEPLDPFSVSHCDALKKRGEREKLNC 249

  Fly   497 IAKQAEETAQRQTIQPITEELA------------PVEENRNSIIMAETNIINNTNCLEQSIEITA 549
            |.|...:.:::|.....:|..|            |:.......::::|.....|. |:..:..|:
Zfish   250 IKKSIVKISRKQVNHKPSESDACNRVSDERGIENPLSSKSELGLLSKTRGSKQTT-LKNFLYETS 313

  Fly   550 VEAEAS--FKADRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRARQSLSNVTTQTSFLDV 612
            .|.|.|  .|.:.:.|..::||...|...|..:.||..:..:.......::.|:|...
Zfish   314 SEREESSNLKPETKNTGMSTELYASSEKPRSFLPKSLTKAIRRKSVHNCKELLTNSEC------- 371

  Fly   613 EQQVTPLFSSTRLPTGQTTGNRRRTIFNMDMDVINESIERMNQSHRMSLALANKAELGESCQVHE 677
                  |:||       .:.:....||..|..:|::.:::  :..|.|..| :.|.|   |.:..
Zfish   372 ------LYSS-------KSSSENEHIFQKDESMIDKPMQK--RQRRTSAGL-HSASL---CALPS 417

  Fly   678 QEPPQAE-------PVPSQEPKRRRLFNPNDEVVISPAM-------SNRKSR----------LSI 718
            :|....|       |..:...||..||:     :.|.||       ||:|.|          :..
Zfish   418 REISDDELFEDFFSPANNASKKRVVLFD-----LTSDAMPTFDLEDSNKKGRRKSYKKQKHGIKD 477

  Fly   719 TGSGSSSSVQKRRRSLATPAKSSSSELCATTPLSKAVTNKEAEKSKSNTEISEASLDAVPEVKKS 783
            :...||.||.....|: ..|:.|.||..|      .|..||   :||.|:..|.|.:...:|
Zfish   478 STVASSDSVNTTEESV-LDARESRSERVA------VVVGKE---NKSTTDGIERSSEMCSKV--- 529

  Fly   784 TSNAGEENEKPKGKSRTRIRTLVHTNMHQEQINVIRKALRKLRGMRLDPTVTQHTTHLVSLEPRR 848
                  ||.| |.|...:.||||.|:|..|:..|:.|.:|.|.|..:...|.:.|:|:||..|||
Zfish   530 ------ENMK-KDKCLKKNRTLVMTSMPTEKQEVVFKVIRNLGGFTVVDDVCESTSHVVSGSPRR 587

  Fly   849 TLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYELTRFSRAIEICRTERQAFGVHYQCELFRF 913
            |:|:|.|:.||.||:|::|::..:...:|::|||:||:....|..|||.::......||.:||..
Zfish   588 TVNILLGIARGCWILSFEWIMWCLEHQQWVSEEPFELSEHFPAAPICRLQQHLSAGEYQQDLFHN 652

  Fly   914 MEPFYVSSLCRPVQFNNMKELLLLGGATLTENRFKAKYIIG--DKRRAEDDRVYLDPYWVLDSIT 976
            ..|.:||...:| ....:|||:.|.|.|:..:..:|...||  :.::.|..| .|...|:||.:|
Zfish   653 QLPMFVSPYSQP-PCGRLKELIKLCGGTVCRSVRQAGICIGGYNGKKPEGSR-SLSEQWILDCVT 715

  Fly   977 NMQIQRFGKYLMK 989
            ::.:..:..|:::
Zfish   716 HLILLPYKNYVLE 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	PTCB-BRCT	187..251	CDD:289507	24/65 (37%)
MCPH1	NP_001163123.1	BRCT	812..873	CDD:237994	24/60 (40%)
mcph1	XP_005157146.1	PTCB-BRCT	16..82	CDD:289507	24/65 (37%)
		BRCT	<559..612	CDD:237994	22/52 (42%)
		BRCT	655..726	CDD:294035	20/72 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573899
Domainoid	1	1.000	50	1.000	Domainoid score	I11711
eggNOG	1	0.900	-	-		E1_KOG4362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3920
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1589580at2759
OrthoFinder	1	1.000	-	-		FOG0006938
OrthoInspector	1	1.000	-	-		oto38715
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4865
SonicParanoid	1	1.000	-	-		X5030
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.830