DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCPH1 and BRCA1

DIOPT Version :9

Sequence 1:	NP_001163123.1	Gene:	MCPH1 / 36272	FlyBaseID:	FBgn0260959	Length:	1028	Species:	Drosophila melanogaster
Sequence 2:	NP_009231.2	Gene:	BRCA1 / 672	HGNCID:	1100	Length:	1884	Species:	Homo sapiens

Alignment Length:	1245	Identity:	243/1245 - (19%)
Similarity:	395/1245 - (31%)	Gaps:	397/1245 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KTYGSVVASSAAAAKKT--AASSTRRPLHDSNLGDFRSK--------AAAPSPKSLSQAPADD-- 66
            :|..||.:||.:....|  ....:...|..|.||..:::        ||..:||.|....:.|
Human   759 QTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNR 823

  Fly    67 -------------------------QAARDRLMLKPALAVSKAISQHRSEFHQDENEAGAE---- 102
                                     ::..|...|:....|||     |..|....|...||
Human   824 NDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSK-----RQSFAPFSNPGNAEEECA 883

  Fly   103 ------GSAAKPDPPIGAATPTRQEGHWARLQQDLNSPNAALRLRAIRALKSPTKSAYNTFDVPL 161
                  ||..|..|.:......::|      .|..|..|.           .|.::...|...|:
Human   884 TFSAHSGSLKKQSPKVTFECEQKEE------NQGKNESNI-----------KPVQTVNITAGFPV 931

  Fly   162 A-----------------------------EQSIITMEE----RNPQE-PPSLPELLKDIVVYVE 192
            .                             |..:||..:    :||.. ||..|     |..:|:
Human   932 VGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFP-----IKSFVK 991

  Fly   193 VRTG----NDNRSEGVKSIIAKMGAQVKDRLTRTTTHVVFKDGLLSTYKKATEWNIPVVSILWIE 253
            .:..    .:|..|...|...:||   .:.:..|.:.:...:...:.:|:|:..||..|.....|
Human   992 TKCKKNLLEENFEEHSMSPEREMG---NENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNE 1053

  Fly   254 ACKVQLKICDPKQFPISNIRMYEYPELFGKMPRVKFMQPDSELNQRPRKRQGTPTSSKDNEPGST 318
            ......:|....:...:.:.....|:| ..|.|:..:||:               ..|.:.|||.
Human  1054 VGSSINEIGSSDENIQAELGRNRGPKL-NAMLRLGVLQPE---------------VYKQSLPGSN 1102

  Fly   319 NK----RAQTGTPTTTTPKNDISRFFRAINHNKPSDDEAIESPATKLLNRISSGCYTPLPAGGTP 379
            .|    :.|.......|...|.|.:..:.|..:|..    .|.|:::.:.             ||
Human  1103 CKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMG----SSHASQVCSE-------------TP 1150

  Fly   380 QLMGTNG---------SGDAVAQKVQAQKSLQFGEQTDSNTP------------QAKPSSTSRPR 423
            ..:..:|         ..|.........||:|.||.:.|.:|            .||...:|...
Human  1151 DDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEEN 1215

  Fly   424 RSTVDPP----------PVMTPPVRTTRRRSCVAEISSPAATDTRMTRRRS-------------- 464
            .|:.|..          .|...|.::||..:...|..|....:..::.:.|
Human  1216 LSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKAS 1280

  Fly   465 -------------SLLTSTVIHEADPT-QTAVAEPRMTRRRSSLLGIAKQAEETAQRQTIQPITE 515
                         ||.:|......|.| .|...:|       .|:|.:||....::.|.:....:
Human  1281 QEHHLSEETKCSASLFSSQCSELEDLTANTNTQDP-------FLIGSSKQMRHQSESQGVGLSDK 1338

  Fly   516 ELAPVEENRNSIIMAETNIINNTNCLEQSIE------ITAVEAEASFKADRRGTLYASELMDISS 574
            ||...:|.|.      |.:..| |..|||::      .:..|:|.|...|..|....|::  :::
Human  1339 ELVSDDEERG------TGLEEN-NQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDI--LTT 1394

  Fly   575 PRRRSVAKSSLELRQE----------------NLAP------RARQSLSNVTTQTSFLDVE---Q 614
            .:|.::..:.::|:||                |..|      .|.:.|.|....||..|..   |
Human  1395 QQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKDSHIHGQ 1459

  Fly   615 QVTPLFS--------------STRLPTGQTTGNRRRTIFNMDMDVINE-----SIERMNQS---- 656
            :...:||              |:..|..|.........|.:..|....     .:||.:.|
Human  1460 RNNSMFSKRPREHISVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPS 1524

  Fly   657 -------HRMSLALANK-----AELGESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVISPAM 709
                   |..|.:|.|:     .||.:...|.||:..::.|....|..    :.|..::..:|.:
Human  1525 LDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETS----YLPRQDLEGTPYL 1585

  Fly   710 SNRKSRLSITGSGSSSSVQKRRRSLATPAKSSSSELCATTPLSKAVTNKEAEKSKSNTEISEASL 774
               :|.:|:......|...:.|    .|..:....:.::|...|....|.||.::|
Human  1586 ---ESGISLFSDDPESDPSEDR----APESARVGNIPSSTSALKVPQLKVAESAQS--------- 1634

  Fly   775 DAVPEVKKSTSNAG----EEN---EKPKGKSRT-RIR---TLVHTNMHQEQINVIRKALRKLRGM 828
               |....:|..||    ||:   |||:..:.| |:.   ::|.:.:..|:..::.|..|| ..:
Human  1635 ---PAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARK-HHI 1695

  Fly   829 RLDPTVTQHTTHLV-----SLEPRRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYEL--- 885
            .|...:|:.|||:|     .....|||....|:..|.|:|||.||..||:..|.:||..:|:
Human  1696 TLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGD 1760

  Fly   886 ------------------TRFSRAIEICRTERQAFGVHYQCELFRFMEPF---------YVSSLC 923
                              .:..|.:|||     .:|            ||         ::..||
Human  1761 VVNGRNHQGPKRARESQDRKIFRGLEIC-----CYG------------PFTNMPTDQLEWMVQLC 1808

  Fly   924 RPVQFNNMKELLLLGG----------ATLTENRFKAKYIIGDKRRAEDDRVYLDPYWVLDSITNM 978
            .......:....|..|          |...:|.|.|   ||....|.    .:...|||||:...
Human  1809 GASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHA---IGQMCEAP----VVTREWVLDSVALY 1866

  Fly   979 QIQRFGKYLM 988
            |.|....||:
Human  1867 QCQELDTYLI 1876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	PTCB-BRCT	187..251	CDD:289507	13/67 (19%)
MCPH1	NP_001163123.1	BRCT	812..873	CDD:237994	22/65 (34%)
BRCA1	NP_009231.2	RING	23..68	CDD:238093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..270
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..338
		BRCT_assoc	345..507	CDD:289581
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..709
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1216		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1322..1387		18/71 (25%)
		Interaction with PALB2. /evidence=ECO:0000269\|PubMed:19369211	1397..1424		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1586..1617		5/34 (15%)
		BRCT	1671..1745	CDD:237994	23/74 (31%)
		BRCT	1779..1863	CDD:214602	22/107 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810