DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCPH1 and Brca1

DIOPT Version :9

Sequence 1:	NP_001163123.1	Gene:	MCPH1 / 36272	FlyBaseID:	FBgn0260959	Length:	1028	Species:	Drosophila melanogaster
Sequence 2:	NP_036646.2	Gene:	Brca1 / 497672	RGDID:	2218	Length:	1817	Species:	Rattus norvegicus

Alignment Length:	1106	Identity:	225/1106 - (20%)
Similarity:	376/1106 - (33%)	Gaps:	284/1106 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SSTRRPLHDSNLGDFRS-KAAAPSPKSLSQAPADDQAARDRLMLKPALAVSKAISQHRSEFHQDE 96
            |..|.|..|..|...|| .:..||||..|:....::..::...:....||:..:.   ......|
  Rat   863 SKLRSPQKDCTLVGARSVPSREPSPKVTSRGEQKERQGQEESEISHVQAVTVTVG---LPVPCQE 924

  Fly    97 NEAGAEGSAAKPDPPIGAATPTRQEGHWARLQQDLN-------SPNAALRLRAIRALKSPTKSAY 154
            .:.||....|    .:....|:   .|:...:..||       |.|:..|...     ||.:|:.
  Rat   925 GKPGAVTMCA----DVSRLCPS---SHYRSCENGLNTTDKSGISQNSHFRQSV-----SPLRSSI 977

  Fly   155 NTFD-VPLAEQSIITMEERNPQEPPSLPELLKDIVVYVEVRTGNDNRSEGVK-----SIIA--KM 211
            .|.: ..|.|.......||......::...:..|        ..:||.:..:     |:|.  ..
  Rat   978 KTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTI--------SQNNRGDACQEASSGSVIEVHST 1034

  Fly   212 GAQVKDRLTRTTTHVVFKDGLL-STYKKATEWNIPVVSILWIEACKVQLKICDPKQFPISNIRMY 275
            |..|:.:|.|.....|....|| ||....::.:.| ||..::| .|.:.|.......|.......
  Rat  1035 GENVQGQLDRNRGPTVNTVSLLDSTQPGVSKQSAP-VSDKYLE-IKQESKAVSADFSPCLFSDHL 1097

  Fly   276 EYPELFGKMPRVKFMQPDS-----ELNQRPRKRQGTPTSSKDNEPGSTNKRAQTGTPTTTT---P 332
            |.|....|:.:|....||.     |:.:.....:|..|.......||..:|..:..|:..|   .
  Rat  1098 EKPMRSDKIFQVCSETPDDLLDDVEIQENASFGEGGITEKSAIFNGSVLRRESSRIPSPVTHASK 1162

  Fly   333 KNDISRFFRAINHNKPSDD-EAIESPATK-LLNRISSGCYTPLPAGGTPQLMGTNGSGDAVAQKV 395
            ...:.|..|.:..::.||. |..:.|..: ||:|:||          ||:|   ......|.|:|
  Rat  1163 SRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSS----------TPEL---TRCSSVVTQRV 1214

  Fly   396 QAQKSLQFGEQTDSNTPQAKPSSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEISSPAATDTRMT 460
                            |: |...|..||:|::.               .|..|:....|:
  Rat  1215 ----------------PE-KAKGTQAPRKSSIS---------------DCNNEVILVEAS----- 1242

  Fly   461 RRRSSLLTSTVIHEADPTQTAVAEPRM-TRRRSSLLGIAKQAEETAQRQTIQPITEELAPVEENR 524
                        .|...::.|.....| :.:.|:.||  ..|...:|.....|.:::.....||.
  Rat  1243 ------------QEYQFSEDAKCSGSMFSSQHSAALG--SPANALSQDPDFNPPSKQRRHQAENE 1293

  Fly   525 NSIIMAETNIINNTN---CLEQSIEITAVEAEASFKADRRGTLYASEL--------MDISSPRRR 578
            .:.:..:..|.::.:   |||::.:    :.|.|...|...:.|.||.        .||.:.::|
  Rat  1294 EAFLSDKELISDHEDMAACLEEASD----QEEDSIIPDSVASGYESEANLSEDCSQSDILTTQQR 1354

  Fly   579 SVAKSSLELRQENLA------------------------------PRARQSLSNVTTQTS----- 608
            :..|.:|...|:.:|                              |...|:.|.....||
  Rat  1355 ATMKDNLIKLQQEMAQLEAVLEQHGSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINE 1419

  Fly   609 ---------FLDVEQQVTPLFSSTRLPTG-QTTGNRRRTIFNMDM-----DVINESIERMNQSHR 658
                     ..|.:.|..|   ...||:| :.:|.||.:.|...:     .....|....|::..
  Rat  1420 NPVSQNPKRACDDKSQPQP---PDGLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNST 1481

  Fly   659 MSLALANKAELGESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVISPAMSNRKSRLSITGSGS 723
            ....|....||.:||:.|.              ...|...|..::..:|.:   :|.:|:..|..
  Rat  1482 SQEELLQPVELEKSCEPHN--------------LTGRSCLPRQDLEGTPYL---ESGISLFSSRD 1529

  Fly   724 SSSVQKRRRSLATPAKSSSSELCATTPLSKAVTNKEAEKSKS------NTEISEASLDAVPEVKK 782
            ..|...:..:|...|.:|:|.|       |....:.|...:|      :|.:.|......|||..
  Rat  1530 PDSESPKVPALVCTAPASTSAL-------KISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTS 1587

  Fly   783 STSNAGEENEKPKGKSRTRIRTLVHTNMHQEQINVIRKALRKLRGMRLDPTVTQHTTHLV----- 842
            |...|            .|..::|.:.:..:::.:::|...|.| :.|...:|:.|||::
  Rat  1588 SKERA------------ERDISMVVSGLTPKEVMIVQKFAEKYR-LALTDVITEETTHVIIKTDA 1639

  Fly   843 SLEPRRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYEL------------TRFSRAIEIC 895
            .....|||....|:..|.|||||.||:.||:..|.::...:|:            .|.||..:
  Rat  1640 EFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLLSVHEFEVKGDVVTGSNHQGPRRSRESQ-- 1702

  Fly   896 RTERQAFGVH-YQCELFRFMEPFYVSSLCRPVQFNNMKELLLLGGAT------------LTENR- 946
              |:...|:. |.||.|..|....:..:.:....:.:|||.||...|            .||:.
  Rat  1703 --EKLFEGLQIYCCEPFTNMPKDELERMLQLCGASVVKELPLLTRDTGAHPIVLVQPSAWTEDND 1765

  Fly   947 -------FKAKYIIGDKRRAEDDRVYLDPYWVLDSITNMQIQRFGKYLMKSAIISADGIRYEDPR 1004
                   .|.:.::.|              ||||||:..:.:....||:::.....||...:|..
  Rat  1766 CPDIGQLCKGRLVMWD--------------WVLDSISVYRCRDLDAYLVQNITCGRDGSEPQDSN 1816

  Fly  1005 D 1005
            |
  Rat  1817 D 1817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	PTCB-BRCT	187..251	CDD:289507	17/71 (24%)
MCPH1	NP_001163123.1	BRCT	812..873	CDD:237994	21/65 (32%)
Brca1	NP_036646.2	RING-HC_BRCA1	18..65	CDD:319412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..347
		BRCT_assoc	343..504	CDD:403887
		Nuclear localization signal. /evidence=ECO:0000255	497..503
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..560
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..768
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	875..907		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..982		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1180		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1259..1290		6/32 (19%)
		Interaction with PALB2. /evidence=ECO:0000250	1354..1381		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1373..1534		30/180 (17%)
		BRCT_BRCA1_rpt1	1596..1692	CDD:349367	25/96 (26%)
		BRCT_BRCA1_rpt2	1703..1800	CDD:349353	24/110 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900