DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MCPH1 and Mcph1

DIOPT Version :9

Sequence 1:NP_001163123.1 Gene:MCPH1 / 36272 FlyBaseID:FBgn0260959 Length:1028 Species:Drosophila melanogaster
Sequence 2:XP_225006.7 Gene:Mcph1 / 306594 RGDID:1560642 Length:836 Species:Rattus norvegicus


Alignment Length:925 Identity:228/925 - (24%)
Similarity:333/925 - (36%) Gaps:246/925 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 LKDIVVYVEV--RTGNDNRSEGVKSIIAKMGAQVKDRLTRTTTHVVFKDGLLSTYKKATEWNIPV 246
            |||:|.||||  ..|.:|.|:.....:..|||.|...|.:..|||:||||..||:.||.:....:
  Rat    32 LKDVVAYVEVWSSKGTENYSKTFTKQLEDMGATVSKTLNKQVTHVIFKDGYQSTWDKAQKIRAKL 96

  Fly   247 VSILWIEACKVQLKICDPKQFPISN--------IR-----------MYEYPE-------LFGKM- 284
            ||:||:|.|::.....|...||..|        ||           :.:.||       .|.|| 
  Rat    97 VSVLWVEKCRMAGARVDESLFPAVNTDEHLPNLIRRKHKCMQPKDFIPKTPENDKRLQKKFEKMA 161

  Fly   285 --------------PRVKFMQPDS------------ELNQRPRKRQG-TPTSSKDNEPGSTNKRA 322
                          |.:.|..|.|            .|.:...||:. :||||:..|....|   
  Rat   162 EELQRQKAALDDDVPVLMFESPQSLVYSSPVNMMKKRLQEMKEKRENLSPTSSQMLEQSQQN--- 223

  Fly   323 QTGTPTTTTPKNDISRFFRAINHNKPSDDEAIESPATKLLNRISSGCYTPL--PAGGTPQLMGTN 385
                |..:..|..::     ::|...|.||:           .:||.:...  |.|...:.:| .
  Rat   224 ----PCVSLLKTSLN-----MSHQPSSSDES-----------FASGSHLSFDGPCGDQERKLG-R 267

  Fly   386 GSGDAVAQKVQAQKSLQ----FGEQTDSNTPQAKP-SSTSRPRRSTVDPPPVMTPPVRTTRRRSC 445
            .|.:.......:...|:    :|..:.::..|..| .:...|.:..|:.....|..|..::|:. 
  Rat   268 SSNEMARMTCPSSPVLRASSFYGSASSNHLRQPSPQKAADTPSKEGVNQQKEATSEVTDSKRKQ- 331

  Fly   446 VAEISSPAATDTRMTRRRSSLLTSTVIHEADPTQTAVAEPRMTRRRSSLLGIAKQAEETAQRQTI 510
            .|.:|...|.:........|::...|:| .:|..:.....|.....|...|..|:..:......:
  Rat   332 AAGVSQGMADEKHCLSPTKSVIEERVVH-LEPKSSPAKRKRTADLGSPSKGKLKKRYKRKSTPAV 395

  Fly   511 QPITEELAPVEENRNSIIMAETNIINNTNCLEQSIEITAVEAEASFKADRRGTLYASELMDISSP 575
            |....:.:|         .:.|..|..|..:|                       ||...|..||
  Rat   396 QLFKSDCSP---------QSTTRPIPGTPDVE-----------------------ASSYEDYFSP 428

  Fly   576 RRRSVAKSSLELRQENLAPRARQSLSNVTTQTSFLDVEQQVTPLFSSTRLPTGQTTGN------- 633
                          :||..|                         :|.|||..|...:       
  Rat   429 --------------DNLKER-------------------------NSGRLPEAQLLASPSLFRCK 454

  Fly   634 -----RRRTIFNM-DMDVINESIERMNQSHRMSLALANKAELGESCQVHEQEPPQAEPV------ 686
                 .|:.:..| |...|.|.....|.|..:|.:         :|.:   |.|..|.|      
  Rat   455 GLSKWERKNMLEMCDFTCIGEKHRSTNISDLISKS---------TCSL---EKPDKEDVNTASTC 507

  Fly   687 -------PSQEPKRRRLFNP------------NDEVVISPAMSNRKSRLSITG-SGSSSSVQKRR 731
                   ....|.:||...|            :.:::.|||.       .||. .|||:..:   
  Rat   508 LPLLGTSADDSPGQRRHPGPQPREDTGPEGSSHPDILYSPAH-------HITPLKGSSTETR--- 562

  Fly   732 RSLATPAKSSSSELCATTPLSKAVTNKEAEK------SKSNTEISEASLDAVPEVKKS------- 783
                .|.....|....|||.:.|....||..      ...|.|..|......|...|:       
  Rat   563 ----DPGDGKGSPKEGTTPPASASPEGEAHSCNLSLGEDRNVEEKENVATGYPGSVKNGLGRPDP 623

  Fly   784 --TSNAG--EENEKPK--GKSRTRIRTLVHTNMHQEQINVIRKALRKLRGMRLDPTVTQHTTHLV 842
              :|..|  ...||||  ||.:...||||.|:|..||.::|.:.:..|||....|.|.:.|||::
  Rat   624 SDSSYRGLVRPQEKPKNSGKEKEPTRTLVMTSMPSEQQDLIIQVVSTLRGFSFAPEVCESTTHVL 688

  Fly   843 SLEPRRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYELTRFSRAIEICRTERQAFGVHYQ 907
            ..:..||||:|.|:.||.||:||||||.|:..|.||:|||:||.....|..|||.||......|:
  Rat   689 VGKSVRTLNVLMGIARGCWILSYQWVLLSLELGHWISEEPFELFETFPAAPICRRERHLSTQQYR 753

  Fly   908 CELFRFMEPFYVSSLCRPVQFNNMKELLLLGGATLTENRFKAKYIIGDKRRAEDDRV-YLDPYWV 971
            ..||......:::....|.: ..:.||:||.|..::.....|..|||..:...:.|: ||...||
  Rat   754 GTLFANQPKMFIAPASSPPR-AKLCELVLLCGGQVSPAPQLASLIIGPYKGKREARIQYLSEKWV 817

  Fly   972 LDSITNMQIQRFGKY 986
            |||||..:|..|..|
  Rat   818 LDSITQHKICDFNNY 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCPH1NP_001163123.1 PTCB-BRCT 187..251 CDD:289507 26/65 (40%)
BRCT 812..873 CDD:237994 28/60 (47%)
Mcph1XP_225006.7 PTCB-BRCT 35..101 CDD:289507 26/65 (40%)
Microcephalin 246..608 CDD:289062 81/461 (18%)
BRCT 657..719 CDD:237994 28/61 (46%)
BRCT <769..833 CDD:294035 23/65 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334692
Domainoid 1 1.000 51 1.000 Domainoid score I11308
eggNOG 1 0.900 - - E1_KOG4362
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 201 1.000 Inparanoid score I3698
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1589580at2759
OrthoFinder 1 1.000 - - FOG0006938
OrthoInspector 1 1.000 - - oto96814
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR14625
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5030
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.990

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