DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCPH1 and Mcph1

DIOPT Version :9

Sequence 1:	NP_001163123.1	Gene:	MCPH1 / 36272	FlyBaseID:	FBgn0260959	Length:	1028	Species:	Drosophila melanogaster
Sequence 2:	XP_011240358.1	Gene:	Mcph1 / 244329	MGIID:	2443308	Length:	883	Species:	Mus musculus

Alignment Length:	944	Identity:	223/944 - (23%)
Similarity:	346/944 - (36%)	Gaps:	217/944 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 LKDIVVYVEV--RTGNDNRSEGVKSIIAKMGAQVKDRLTRTTTHVVFKDGLLSTYKKATEWNIPV 246
            |||:|.||||  ..|.:|.|......:..|||.|...|.:..|||:||||..||:.||.:....:
Mouse    12 LKDVVAYVEVWSSKGTENYSRTFAKQLEDMGATVSKTLNKQVTHVIFKDGYQSTWDKAQKTGAKL 76

  Fly   247 VSILWIEACKVQLKICDPKQFPISNIRMYEYPELFGKMPRVKFMQP----------DSELNQRPR 301
            ||:||:|.|::...:.|...||..|...: .|.|..|  :.|.|||          |..|.::..
Mouse    77 VSVLWVEKCRMAGALVDESLFPAVNTDEH-LPNLSRK--KHKCMQPKDFILKTPENDKRLQKKFE 138

  Fly   302 K------RQ-------------GTPTSSKDNEPGSTNKR--------AQTGTPT----------- 328
            |      ||             .:|.|...:.|.:..||        .:..:||
Mouse   139 KMAEELQRQKAALDDDVPVLLFESPRSLVYSSPVNVMKRRLQDMKEKRENLSPTCKWLQCRMKRM 203

  Fly   329 --------------------TTTPKNDISRFFRA---INHNKPSDDEAIESPA-----------T 359
                                ..:.:|.....|..   |:|...|.||:..|.:           .
Mouse   204 SAGELQKKGYLISTLASQMLEQSQQNPCVSLFETSLNISHQPLSSDESFASGSHSSFGDSCGDQE 268

  Fly   360 KLLNRISSGCYTPLPAGGTPQLMGTNGSGDA-----------------VAQKVQAQKSLQFGEQT 407
            :.|.| |:...|.:....:|.|..::..|.|                 ..:.:..||... |...
Mouse   269 RKLGR-SANEMTTVTCPSSPVLRASSFYGSASPNHLRQPRPQKAPDSPSKESINCQKDAT-GAVA 331

  Fly   408 DSNTPQAKPSSTS--------RPRRSTVDPPPVMTPPVRTTRRRSCVAEI-SSPAATDTRMTRRR 463
            ||...||...|..        .|..|.::...|...|..::.:|...|:: |||.....:..:|:
Mouse   332 DSERKQAAGVSQGVPDEKLCLSPTMSIIEEHQVRLGPKNSSAKRKRAADLGSSPKGKLKKRYKRK 396

  Fly   464 SSLLTSTVIHEADPTQTAVAEPRMTRRRSSLLGIAKQAEETAQRQTIQPITEELAPVEENRNSII 528
            |:|.......:..|..|....|......:|      ..|:......::....|..|.|..:
Mouse   397 SALAIQLFKSDQSPPSTIRLIPGTPDVEAS------SYEDYFSPDNLKERNSERLPPEAQQ---- 451

  Fly   529 MAETNIINNTNCLEQSIEITAVEAEASFKADRRGTLYASELMDIS--SPRRRSVAKSSLELRQEN 591
            :|..::.   :|...|            |.:||..|   |:.|.:  ..:.||::..|      :
Mouse   452 LASPSLF---HCRGLS------------KWERRNML---EMCDFTCIGEKHRSISSIS------D 492

  Fly   592 LAPRARQSLSNV------TTQTSFLDVE----------QQVTPLFSSTRLPTGQTTGNRRRTIFN 640
            |..::..||...      |..|..|.||          .|..|.......|.|.:
Mouse   493 LISKSASSLEKPVKEEVNTASTCLLLVETSANDSPGLCSQPGPQLRDDTGPEGSS---------- 547

  Fly   641 MDMDVINESIERMNQSHRMSLALANKAELGESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVI 705
             ..|.::.|      :|.::....|..|        .::|...:..|.:........:|.|||.|
Mouse   548 -HPDTLSSS------AHHITPLKGNSTE--------TRDPGDGKGSPKEGSTPPASASPEDEVHI 597

  Fly   706 SPAMSNRKSRLSITGSGSSSSVQK---RRRSLAT---------PAKSSSSELCATTPLSKAVTNK 758
                    ..||:   |...:|:|   .:.::||         |.:...|:...|..:......|
Mouse   598 --------CNLSL---GEDCNVEKSVEEKENIATGYSESVKNGPGRPDPSDSSCTGLVRPQQKPK 651

  Fly   759 EAEKSKSNTEISEASLDAVPEVKKSTSNAGEENEKPKGKSRTRIRTLVHTNMHQEQINVIRKALR 823
            ::||.:.....:.......|:........|.:::..........||||.|:|..|:..:|.:.:.
Mouse   652 KSEKEEKAGGFASVRSGVSPQGSVLQYITGVDSQFKSCSFLQPTRTLVMTSMPSEKQTLIIQVVS 716

  Fly   824 KLRGMRLDPTVTQHTTHLVSLEPRRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYELTRF 888
            .|:|....|.|.:.|||::..:..||||:|.|:.||.||:||:|||.|:..|.||:|||:||:..
Mouse   717 TLKGFSFAPEVCETTTHVLVGKSARTLNVLMGIARGCWILSYEWVLLSLELGHWISEEPFELSET 781

  Fly   889 SRAIEICRTERQAFGVHYQCELFRFMEPFYVSSLCRPVQFNNMKELLLLGGATLTENRFKAKYII 953
            ..|..|||.||......||..||......:::....|.: ..:.||:||.|..::.....|..||
Mouse   782 FPAAPICRLERHLSTQQYQGTLFANQPKMFIAPASSPPR-AKLCELVLLCGGQVSPAPQLASLII 845

  Fly   954 GDKRRAEDDRV-YLDPYWVLDSITNMQIQRFGKY 986
            |..:..:..|: ||...|||||||..:|..|..|
Mouse   846 GPYKGKKKARIQYLSEKWVLDSITQHKICDFNNY 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	PTCB-BRCT	187..251	CDD:289507	26/65 (40%)
MCPH1	NP_001163123.1	BRCT	812..873	CDD:237994	25/60 (42%)
Mcph1	XP_011240358.1	BRCT_microcephalin_rpt1	14..92	CDD:349348	31/77 (40%)
		Microcephalin	252..620	CDD:371997	78/439 (18%)
		BRCT_microcephalin_rpt2	696..771	CDD:349368	32/74 (43%)
		BRCT_microcephalin_rpt3	797..873	CDD:349382	24/76 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830980
Domainoid	1	1.000	51	1.000	Domainoid score	I11525
eggNOG	1	0.900	-	-		E1_KOG4362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006938
OrthoInspector	1	1.000	-	-		oto93272
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14625
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4865
SonicParanoid	1	1.000	-	-		X5030
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010