Protein Alignment MCPH1 and W04A8.1

DIOPT Version :9

• Sequence 1: NP_001163123.1
• Gene: MCPH1 / 36272
• FlyBaseID: FBgn0260959
• Length: 1028
• Species: Drosophila melanogaster
• Sequence 2: NP_493420.1
• Gene: W04A8.1 / 173252
• WormBaseID: WBGene00012236
• Length: 667
• Species: Caenorhabditis elegans
• Alignment Length: 862
• Identity: 161/862 - (18%)
• Similarity: 281/862 - (32%)
• Gaps: 300/862 - (34%)

  Fly   158 DVPLAEQSIITMEERNPQEPPSLPELLKDIVVYVEVRTGNDNRSEGVKSIIAKMGAQVKDRLTRT 222
            :||.:.:.::..::  .:|.|.....|...|:.:........|....|.:| :|||:::..:...
 Worm    80 EVPDSREDVLACDD--DEEVPESVGYLAGTVIVLSAGCCLPIRHHLSKKLI-EMGAEIQKTIDNR 141

  Fly   223 TTHVV---FKDGLLSTYKKATEWNIP-VVSILWIEACKVQLKICDPKQFPISNIRMYEYPELFGK 283
            |||:|   :.|..|.....:.:...| :|.:.||:.|....:.|....|.:..:|.
 Worm   142 TTHIVVDRYADEKLVGEAMSRKPEPPMMVDVKWIQECLDNRQKCKENDFSMIGLRY--------- 197

  Fly   284 MPRVKFMQPDSELNQRPRK----RQGTPTSSKDNEPGSTNKRAQTGTPTTTTPKNDISRFFRAIN 344
                        |.|..|:    |:.||...::                        ..|:..:.
 Worm   198 ------------LKQSCRRLSSFREPTPLGDEE------------------------ETFWEDME 226

  Fly   345 HNKPSDDEAIESPATKLLNRISS--GCYTPLPAGGTPQLMGTNGSGDAVAQKVQAQKSLQFGEQT 407
            ::.|:|...:.....||..|:.:  .|...:|.                         ::|
 Worm   227 NDAPTDPAKLLEQIRKLSERLDALMDCKPHVPV-------------------------IRF---- 262

  Fly   408 DSNTPQAKPSSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEISSPAATDTRMTRRRSSLLTSTVI 472
            :.::|..       |.|....||   .||.:...:|...:.|.||.|.....|    |:.||:.:
 Worm   263 EYHSPDC-------PTRQQPQPP---APPAKKASQRPKNSRIPSPEALQQLFT----SISTSSTL 313

  Fly   473 HEADPTQTAVAEPRMTRRRSSLLGIAKQAEETAQRQTIQPITEELAPVEENRNSIIMAETNIINN 537
                            |||.|..|...:..|        |....|...|.|         |.:.|
 Worm   314 ----------------RRRRSFTGFVLEHRE--------PGNAALEVQEAN---------NDVRN 345

  Fly   538 TNCLEQSIEITAVEAEASFKA------DRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRA 596
            |    .:.|:.|.:...:.||      |.|.|: |::|..|    |..:||:| :|.:.....::
 Worm   346 T----WNPELGAKKPRKTRKAPQKTVNDMRKTM-AADLTTI----RDVLAKNS-DLNRARTPKKS 400

  Fly   597 RQSLSNVTTQTSFLDVEQQVTPLFSSTRLPTGQTTGNRRRTIFNMDMDVINESIERMNQSHRMSL 661
            ::...|..::...:.|...                          |.|:         ||...||
 Worm   401 KKPAKNSNSRQKMMPVHVD--------------------------DSDI---------QSALASL 430

  Fly   662 ALANKAELGESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVIS--PAMSNRKSRLSITGSGSS 724
            .:   :|....|.|....|.::. |.:|..||.   ..:|:..||  .|...||:
 Worm   431 TI---SEAPRECSVQILVPTRSN-VINQLQKRH---EEDDDDFISDVSAFLQRKT---------- 478

  Fly   725 SSVQKRRRSLATPAKSSSSELCAT-TPLSKAV-TNKEAEKSKSNTEISEASLDAVPEVKKSTSNA 787
               .|:.|:|   .::|.:|:..| :|:.|.: |.....|...:|||.|
 Worm   479 ---MKKSRNL---GENSKNEVIFTGSPIEKKLKTIVRRFKMTISTEIDE---------------- 521

  Fly   788 GEENEKPKGKSRTRIRTLVHTNMHQEQINVIRKALRKLRGMRLDPTVTQHTTHLVSLEPRRTLNL 852
                                                            :.|..:||...:|||.:
 Worm   522 ------------------------------------------------ERTLCVVSRHGKRTLLV 538

  Fly   853 LRGLMRGVWIVSYQWVLASIRAGKWINEEPYELTRFSRAIEICRTERQAFGVHYQCELF-RFMEP 916
            ||.:...|.||..||:..|....:.:....|....:.| ||             ..::| .|...
 Worm   539 LRAICCDVPIVRPQWLEESFEDSQLLPSSDYIYQEWLR-IE-------------NLKIFANFHLR 589

  Fly   917 FYVSSLCRPVQFNNMKELLLLGGATLTENRFKAKYIIGDKR---RAEDDRVY--LDPYWVLDSIT 976
            .:::..|.| ...::..::...|..:|.:..:|..:|..:.   .||:|..:  ..|.:|:|||:
 Worm   590 MWIAPECTP-DSADLAWMIEKCGGKVTRHLHRADLVIAPENWEIPAENDVEFELATPLFVIDSIS 653

  Fly   977 NMQIQRFGKYLMKSAII 993
            ..::|.|.:|   |.||
 Worm   654 MAELQNFREY---SVII 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	PTCB-BRCT	187..251	CDD:289507	15/67 (22%)
		BRCT	812..873	CDD:237994	14/60 (23%)
W04A8.1	NP_493420.1	BRCT	106..180	CDD:237994	18/74 (24%)
		BRCT	493..558	CDD:214602	22/128 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006938
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4865
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940