DRSC/TRiP Functional Genomics Resources

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Protein Alignment MCPH1 and bard1

DIOPT Version :10

Sequence 1:NP_001163123.1 Gene:MCPH1 / 36272 FlyBaseID:FBgn0260959 Length:1028 Species:Drosophila melanogaster
Sequence 2:XP_021334679.1 Gene:bard1 / 100147913 ZFINID:ZDB-GENE-030131-5883 Length:653 Species:Danio rerio


Alignment Length:700 Identity:136/700 - (19%)
Similarity:232/700 - (33%) Gaps:216/700 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   417 SSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEISSPAATDTRMTRRRSSLLTSTVIHEADPTQTA 481
            |..||..|..:..|..:..|....:::|    .:||::.|..:....||      ..|:.|:...
Zfish    15 SPKSRKVRCCIHRPVELNTPNGVQQKKS----TASPSSEDLAVFNFSSS------SQESGPSTPP 69

  Fly   482 VAEPRMTRRRSSLLGIAKQAEETAQRQT-IQPITE----ELAPVEENRNSIIMAETNIINNTNCL 541
            .|:.....::..:...::||:...:.:| |:.:.|    :|..:.:..|:...|:.:        
Zfish    70 RAKMNKKTKKKRIGQNSRQAKAAQRPRTWIRSLQERKKLKLEVINKQWNTGEEADVD-------- 126

  Fly   542 EQSIEITAVEAEASFKADRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRARQSLS-NVTT 605
              :|:.|..|.|.....|           |...|.:|...:......:|...|..:::|: |...
Zfish   127 --AIDETGDEDEKMSSGD-----------DNRKPAKRVFFRLPHSQSEETFKPSQQRNLTPNHEK 178

  Fly   606 QTSFLDVEQQVTPLFSSTRLPTGQTTGNRRRTIFNMDMDVINESIERMNQSHRM--SLALANKAE 668
            ...|.|.|||.:...|   ||             :.|...|.|....:|::..:  |.:...|..
Zfish   179 IVEFKDSEQQNSAALS---LP-------------DHDQQPIAEISPELNENELLQPSFSRVRKRS 227

  Fly   669 LGESCQVHEQEPPQAEPVPSQEPKRR----------------RLFNPNDEVVISPAMS------- 710
            ..||.      |.|....|  |||||                :.|.|.:|   .|.:|       
Zfish   228 SSESL------PKQPRITP--EPKRRSSGEGAALIEDSSQSLKTFRPTNE---KPVLSSLGTHDV 281

  Fly   711 -------------------NRKSRLSITGSGSSSSVQKRRRSLATPAKSSSSELCATTPLSK--- 753
                               |.|...::..:.|...|:..|:.||..|..:..:....|||.:   
Zfish   282 LKKSPDVRHKQTCPVYMKRNHKGETALHLAASKGDVEGVRKLLAQGADPNLKDNAGWTPLHEACN 346

  Fly   754 -------------------------------------AVTNKEAEKSKSNTEISEASLDAV---- 777
                                                 ||.....|:..|.:.::...|..|    
Zfish   347 VGHLGVVEELLQQGALLNTPGYQNDSPLHDAIRSGHIAVVKLLVERGASQSVLNIFGLRPVDYAL 411

  Fly   778 -PEVKKSTSNAGEEN-------EKPKGKSRTRIRTLVHTNMHQEQINVIRKALRKLRGMRLDPTV 834
             ||:|:....|.|.:       ..|..|:...: .|:.:.:.|.|...|.:|.:.|.|.:. ...
Zfish   412 TPEMKEVLRVAPEASHLITTSLRPPASKAAGGV-VLIGSELTQTQHKQINRAAQLLGGKQA-KAF 474

  Fly   835 TQHTTHL----VSLEPRRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYEL------TRFS 889
            :...||:    |.:.| .||..|.|::.|.||:::.|:..|::||.|:.|..||.      .|.:
Zfish   475 SSAVTHVVVPDVPIMP-STLTTLHGVLNGCWILNFSWLSCSLQAGSWVKESGYEAGDGPLRARAN 538

  Fly   890 RAIEICRTERQAFGVHYQCELFRFMEP------FYVSSLCRPVQFNNMKELLLLGGATL------ 942
            |.                    ..:.|      ||:....|....:.:.:|:..||..|      
Zfish   539 RG--------------------SLLPPLFDGCFFYMLGSFRKPPKDELLQLVKAGGGQLLKRLPK 583

  Fly   943 -----TENRFKAKYIIGDKRRAEDDRVYLDPYWVLDSITNMQIQ--RFGK 985
                 |:....|.|    ..:|..|:|....|.:.|..::.:.|  |.||
Zfish   584 PDSDVTQTLNAAAY----HAQAGSDQVLCTQYILYDPQSSYKPQKVRLGK 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCPH1NP_001163123.1 BRCT_microcephalin_rpt1 186..260 CDD:349348
BRCT_microcephalin_rpt2 803..878 CDD:349368 22/78 (28%)
BRCT_microcephalin_rpt3 905..980 CDD:349382 16/91 (18%)
bard1XP_021334679.1 ANKYR <300..420 CDD:440430 20/119 (17%)
ANK repeat 304..334 CDD:293786 6/29 (21%)
ANK repeat 336..367 CDD:293786 3/30 (10%)
ANK repeat 369..400 CDD:293786 4/30 (13%)
BRCT_Bard1_rpt1 444..521 CDD:349366 22/79 (28%)
BRCT_Bard1_rpt2 546..646 CDD:349352 18/87 (21%)
Blue background indicates that the domain is not in the aligned region.

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