DRSC/TRiP Functional Genomics Resources

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Protein Alignment MCPH1 and bard1

DIOPT Version :9

Sequence 1:NP_001163123.1 Gene:MCPH1 / 36272 FlyBaseID:FBgn0260959 Length:1028 Species:Drosophila melanogaster
Sequence 2:XP_021334679.1 Gene:bard1 / 100147913 ZFINID:ZDB-GENE-030131-5883 Length:653 Species:Danio rerio


Alignment Length:700 Identity:136/700 - (19%)
Similarity:232/700 - (33%) Gaps:216/700 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   417 SSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEISSPAATDTRMTRRRSSLLTSTVIHEADPTQTA 481
            |..||..|..:..|..:..|....:::|    .:||::.|..:....||      ..|:.|:...
Zfish    15 SPKSRKVRCCIHRPVELNTPNGVQQKKS----TASPSSEDLAVFNFSSS------SQESGPSTPP 69

  Fly   482 VAEPRMTRRRSSLLGIAKQAEETAQRQT-IQPITE----ELAPVEENRNSIIMAETNIINNTNCL 541
            .|:.....::..:...::||:...:.:| |:.:.|    :|..:.:..|:...|:.:        
Zfish    70 RAKMNKKTKKKRIGQNSRQAKAAQRPRTWIRSLQERKKLKLEVINKQWNTGEEADVD-------- 126

  Fly   542 EQSIEITAVEAEASFKADRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRARQSLS-NVTT 605
              :|:.|..|.|.....|           |...|.:|...:......:|...|..:::|: |...
Zfish   127 --AIDETGDEDEKMSSGD-----------DNRKPAKRVFFRLPHSQSEETFKPSQQRNLTPNHEK 178

  Fly   606 QTSFLDVEQQVTPLFSSTRLPTGQTTGNRRRTIFNMDMDVINESIERMNQSHRM--SLALANKAE 668
            ...|.|.|||.:...|   ||             :.|...|.|....:|::..:  |.:...|..
Zfish   179 IVEFKDSEQQNSAALS---LP-------------DHDQQPIAEISPELNENELLQPSFSRVRKRS 227

  Fly   669 LGESCQVHEQEPPQAEPVPSQEPKRR----------------RLFNPNDEVVISPAMS------- 710
            ..||.      |.|....|  |||||                :.|.|.:|   .|.:|       
Zfish   228 SSESL------PKQPRITP--EPKRRSSGEGAALIEDSSQSLKTFRPTNE---KPVLSSLGTHDV 281

  Fly   711 -------------------NRKSRLSITGSGSSSSVQKRRRSLATPAKSSSSELCATTPLSK--- 753
                               |.|...::..:.|...|:..|:.||..|..:..:....|||.:   
Zfish   282 LKKSPDVRHKQTCPVYMKRNHKGETALHLAASKGDVEGVRKLLAQGADPNLKDNAGWTPLHEACN 346

  Fly   754 -------------------------------------AVTNKEAEKSKSNTEISEASLDAV---- 777
                                                 ||.....|:..|.:.::...|..|    
Zfish   347 VGHLGVVEELLQQGALLNTPGYQNDSPLHDAIRSGHIAVVKLLVERGASQSVLNIFGLRPVDYAL 411

  Fly   778 -PEVKKSTSNAGEEN-------EKPKGKSRTRIRTLVHTNMHQEQINVIRKALRKLRGMRLDPTV 834
             ||:|:....|.|.:       ..|..|:...: .|:.:.:.|.|...|.:|.:.|.|.:. ...
Zfish   412 TPEMKEVLRVAPEASHLITTSLRPPASKAAGGV-VLIGSELTQTQHKQINRAAQLLGGKQA-KAF 474

  Fly   835 TQHTTHL----VSLEPRRTLNLLRGLMRGVWIVSYQWVLASIRAGKWINEEPYEL------TRFS 889
            :...||:    |.:.| .||..|.|::.|.||:::.|:..|::||.|:.|..||.      .|.:
Zfish   475 SSAVTHVVVPDVPIMP-STLTTLHGVLNGCWILNFSWLSCSLQAGSWVKESGYEAGDGPLRARAN 538

  Fly   890 RAIEICRTERQAFGVHYQCELFRFMEP------FYVSSLCRPVQFNNMKELLLLGGATL------ 942
            |.                    ..:.|      ||:....|....:.:.:|:..||..|      
Zfish   539 RG--------------------SLLPPLFDGCFFYMLGSFRKPPKDELLQLVKAGGGQLLKRLPK 583

  Fly   943 -----TENRFKAKYIIGDKRRAEDDRVYLDPYWVLDSITNMQIQ--RFGK 985
                 |:....|.|    ..:|..|:|....|.:.|..::.:.|  |.||
Zfish   584 PDSDVTQTLNAAAY----HAQAGSDQVLCTQYILYDPQSSYKPQKVRLGK 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCPH1NP_001163123.1 PTCB-BRCT 187..251 CDD:289507
BRCT 812..873 CDD:237994 19/64 (30%)
bard1XP_021334679.1 ANK 300..410 CDD:238125 17/109 (16%)
ANK repeat 304..334 CDD:293786 6/29 (21%)
ANK repeat 336..367 CDD:293786 3/30 (10%)
ANK repeat 369..400 CDD:293786 4/30 (13%)
BRCT 444..511 CDD:237994 18/69 (26%)
BRCT 544..642 CDD:214602 19/89 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4362
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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