DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and TEF1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_015405.1	Gene:	TEF1 / 856195	SGDID:	S000006284	Length:	458	Species:	Saccharomyces cerevisiae

Alignment Length:	460	Identity:	361/460 - (78%)
Similarity:	405/460 - (88%)	Gaps:	3/460 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKA 65
            |||||.|||:||||||||||||||||||||||||||||||||||||.|:||||||||||||||||
Yeast     1 MGKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKA 65

  Fly    66 ERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKN 130
            |||||||||||||||||.||.||:|||||||||||||||||||||||:||:|.|.|||||||||:
Yeast    66 ERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEAGISKD 130

  Fly   131 GQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISG 195
            |||||||||||||||:||||.||||||.:  :.|:|::||.||.|::|||:||||..|.||||||
Yeast   131 GQTREHALLAFTLGVRQLIVAVNKMDSVK--WDESRFQEIVKETSNFIKKVGYNPKTVPFVPISG 193

  Fly   196 WHGDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIG 260
            |:||||:|.:||.||:|||:.|.|.|...||||::|:|||..|:|||||.|||||||||||||||
Yeast   194 WNGDNMIEATTNAPWYKGWEKETKAGVVKGKTLLEAIDAIEQPSRPTDKPLRLPLQDVYKIGGIG 258

  Fly   261 TVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYV 325
            |||||||||||:|||.||.||||.:||||||||||||.|::.|||||||||||||||||:|||.|
Yeast   259 TVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLEQGVPGDNVGFNVKNVSVKEIRRGNV 323

  Fly   326 AGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEEN 390
            .||:|.:||||.|.|.|.||||||||||:.||:||||||||||||:|.|:.||.||||||..|::
Yeast   324 CGDAKNDPPKGCASFNATVIVLNHPGQISAGYSPVLDCHTAHIACRFDELLEKNDRRSGKKLEDH 388

  Fly   391 PKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAA 455
            |||:||||||:|..|||||:|||||.|:|||||||||||||||||||||:|: |.....||||||
Yeast   389 PKFLKSGDAALVKFVPSKPMCVEAFSEYPPLGRFAVRDMRQTVAVGVIKSVD-KTEKAAKVTKAA 452

  Fly   456 EKATK 460
            :||.|
Yeast   453 QKAAK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	358/455 (79%)
TEF1	NP_015405.1	PTZ00141	1..443	CDD:185474	352/444 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343901
Domainoid	1	1.000	381	1.000	Domainoid score	I103
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68181
Inparanoid	1	1.050	741	1.000	Inparanoid score	I76
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62187
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	1	1.000	-	-		otm46493
orthoMCL	1	0.900	-	-		OOG6_100227
Panther	1	1.100	-	-	O	PTHR23115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2502
SonicParanoid	1	1.000	-	-		X149
TreeFam	1	0.960	-	-
	15	14.790