DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and HBS1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_013010.3	Gene:	HBS1 / 853959	SGDID:	S000001792	Length:	611	Species:	Saccharomyces cerevisiae

Alignment Length:	473	Identity:	144/473 - (30%)
Similarity:	238/473 - (50%)	Gaps:	68/473 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGI 71
            |::.||:||||:||||..|.|:|....:::..:.|.::|::.|||.|||:||::|:...|||||:
Yeast   167 HLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERERGV 231

  Fly    72 TIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREH 136
            |:.|....|.|.:...||:||||||||:.|.|.|.||||.|:|.|...|..||:|...:|||:||
Yeast   232 TVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFESGFDLDGQTKEH 296

  Fly   137 ALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNM 201
            .|||.:||:..||:.:||||:.:  :|:.|:||||.::..|:..||:....:.:|||||:.|:.:
Yeast   297 MLLASSLGIHNLIIAMNKMDNVD--WSQQRFEEIKSKLLPYLVDIGFFEDNINWVPISGFSGEGV 359

  Fly   202 --LEPSTNM-PWFKG-----------WKVERK-EG-NADGKTLIDALDAILPPARPTDKALRLPL 250
              :|.:..: .|:.|           :|:.:: || |.|...|...|:.|  |::.|...|.|
Yeast   360 YKIEYTDEVRQWYNGPNLMSTLENAAFKISKENEGINKDDPFLFSVLEII--PSKKTSNDLAL-- 420

  Fly   251 QDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEM--------HHEALQEAVPGDN 307
                        ..|::|:|.::||..:...|:..:..|..:::        :||....|:.||.
Yeast   421 ------------VSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGSQQGQSTNHEETDVAIKGDF 473

  Fly   308 VGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKF 372
            |...::....::::.|.:|.....:....|..|..::...:....:..| ||.:         .|
Yeast   474 VTLKLRKAYPEDIQNGDLAASVDYSSIHSAQCFVLELTTFDMNRPLLPG-TPFI---------LF 528

  Fly   373 AEIKEKVDR---------RSGKTTEENPKFIKSGDAAIV--NLVPSK---PLCVEAFQEFPPLGR 423
            ..:||:..|         :....:::..:.:.|...|.|  .|:..|   ||...  .|...|||
Yeast   529 IGVKEQPARIKRLISFIDKGNTASKKKIRHLGSKQRAFVEIELIEVKRWIPLLTA--HENDRLGR 591

  Fly   424 FAVRDMRQTVAVGVIKAV 441
            ..:|...:|:|.|.|..:
Yeast   592 VVLRKDGRTIAAGKISEI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	144/473 (30%)
HBS1	NP_013010.3	HBS1_N	11..73	CDD:401037
HBS1	NP_013010.3	TEF1	161..611	CDD:227581	144/473 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
TreeFam	0	0.000	Not matched by this tool.
	5	4.910