DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and GUF1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_013392.1	Gene:	GUF1 / 850996	SGDID:	S000004280	Length:	645	Species:	Saccharomyces cerevisiae

Alignment Length:	478	Identity:	109/478 - (22%)
Similarity:	166/478 - (34%)	Gaps:	132/478 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITI 73
            |..::.|||.||||.:..|:.....||.....|                .|||||:.||||||||
Yeast    48 NFSIVAHVDHGKSTLSDRLLEITHVIDPNARNK----------------QVLDKLEVERERGITI 96

  Fly    74 DIALWKFETA-----------KYYVTIIDAPGHRDFIKNMITGTSQADC--AVLIVAAGTGEFEA 125
                 |.:|.           .|.:.:||.|||.||...:  ..|.|.|  |:|:|.|..|
Yeast    97 -----KAQTCSMFYKDKRTGKNYLLHLIDTPGHVDFRGEV--SRSYASCGGAILLVDASQG---- 150

  Fly   126 GISKNGQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEAR------YEEIKKEVSSYIKKIGYN 184
               ...||..:..|||:||:| ||..:||:|.:.....:.:      :|..::::.....|.|.|
Yeast   151 ---IQAQTVANFYLAFSLGLK-LIPVINKIDLNFTDVKQVKDQIVNNFELPEEDIIGVSAKTGLN 211

  Fly   185 ------PAAVAFVPISGWHGDNMLEPSTNMP-----------WFKGWKVERKEGNADGKTLIDAL 232
                  ||.:..:|           |.|..|           |:..:        .....|::.:
Yeast   212 VEELLLPAIIDRIP-----------PPTGRPDKPFRALLVDSWYDAY--------LGAVLLVNIV 257

  Fly   233 DAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTV---VVFAPANITTEVKSVEM 294
            |.   ..|..||.:....::.|::..||.:...|..||.||.|.|   |:....:...::....|
Yeast   258 DG---SVRKNDKVICAQTKEKYEVKDIGIMYPDRTSTGTLKTGQVGYLVLGMKDSKEAKIGDTIM 319

  Fly   295 HHEALQE-----------------AVPGDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTA 342
            |...:.|                 |.|.|.:.|...:..:..|    |..|......:..::...
Yeast   320 HLSKVNETEVLPGFEEQKPMVFVGAFPADGIEFKAMDDDMSRL----VLNDRSVTLERETSNALG 380

  Fly   343 QVIVLNHPGQI-----------ANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKFIKS 396
            |...|...|.:           ..|...::...|.....:|.:.|:|:        ..||.....
Yeast   381 QGWRLGFLGSLHASVFRERLEKEYGSKLIITQPTVPYLVEFTDGKKKL--------ITNPDEFPD 437

  Fly   397 GDAAIVNLVPSKPLCVEAFQEFP 419
            |....||:.......:||....|
Yeast   438 GATKRVNVAAFHEPFIEAVMTLP 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	109/478 (23%)
GUF1	NP_013392.1	LepA	38..645	CDD:223557	109/478 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910