DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1alpha1 and gtpbp1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001072172.1	Gene:	gtpbp1 / 594925	XenbaseID:	XB-GENE-951182	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	524	Identity:	111/524 - (21%)
Similarity:	198/524 - (37%)	Gaps:	146/524 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IHINIVVIGHVDSGKSTTTGHLIYKCGGID-------------KRTIEK------------FEKE 45
            :.:.:.|:|:||:||||..|.|.:  |.:|             |..||.            |:..
Frog   148 LEVRVAVVGNVDAGKSTLLGVLTH--GELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSH 210

  Fly    46 AQEMGK-----GSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITG 105
            .|.:.|     ||.::..:.:|                    :...:|.||..||..::|..:.|
Frog   211 GQVVNKPDSHGGSLEWTKICEK--------------------SSKIITFIDLAGHEKYLKTTVFG 255

  Fly   106 TS--QADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYE 168
            .:  ..|..:|:|.:     .|||.  |.|:||..||..|.|...:| |.|:|...        .
Frog   256 MTGHLPDFCMLMVGS-----NAGIV--GMTKEHLGLALALNVPVFVV-VTKIDMCP--------A 304

  Fly   169 EIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTNM------PWFKGWKVERKEGNADGKT 227
            .|.:|....::::..:|.. ..:|:...:.|:::..::|.      |.|       :..|..|:.
Frog   305 NILQETLKLLQRLLKSPGC-RKIPVLVQNKDDVIVTASNFSSERMCPIF-------QISNVTGEN 361

  Fly   228 --LIDALDAILPPARPT--DKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAP---ANI 285
              |:.....:|.|...:  ::.....:.|.|.:.|:|||..|....|::|...:::..|   .|.
Frog   362 MELLKMFLNLLSPRSSSREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDLLLLGPDPLGNF 426

  Fly   286 TT-EVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNH 349
            |: .|||:......::|...|....|.:|.:....:|:|.|....:.| |:.:.:|.|:::||:|
Frog   427 TSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLN-PQASWEFEAEILVLHH 490

  Fly   350 PGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKFIKSGDAAIVNLVPSKPLCVEA 414
            |..|:..|..::.|.:.              |::......:...:::||.|.|:.
Frog   491 PTTISPRYQAMVHCGSI--------------RQTATILSMSRDCLRTGDKATVHF---------- 531

  Fly   415 FQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTK--------------------AAEKAT 459
              .|.....:...|.|.....|..|||       |.:||                    :.:|:.
Frog   532 --RFIKTPEYLHIDQRLVFREGRTKAV-------GTITKLLQSTNNLPMNSKPQQVKMQSTKKSP 587

  Fly   460 KGKK 463
            .|||
Frog   588 HGKK 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	107/516 (21%)
gtpbp1	NP_001072172.1	SelB	65..563	CDD:332589	107/494 (22%)
gtpbp1	NP_001072172.1	GTPBP1_like	151..375	CDD:206728	58/269 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910