DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and Hbs1l

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_006512866.1	Gene:	Hbs1l / 56422	MGIID:	1891704	Length:	685	Species:	Mus musculus

Alignment Length:	444	Identity:	171/444 - (38%)
Similarity:	260/444 - (58%)	Gaps:	20/444 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAE 66
            ||:.  :|:|||||||:||||..||::|..|.::|||:.|:|:|:::.||.||.||||||:...|
Mouse   255 GKQL--LNLVVIGHVDAGKSTLMGHMLYLLGNVNKRTMHKYEQESKKAGKASFAYAWVLDETGEE 317

  Fly    67 RERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNG 131
            ||||:|:|:.:.||||....:|::|||||:|||.|||||.:|||.|||:|.|..||||||....|
Mouse   318 RERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGG 382

  Fly   132 QTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGW 196
            |||||.||..:|||.||.|.|||||  :..:.:.|::||..::..::|:.|:..:.|||:|.||.
Mouse   383 QTREHGLLVRSLGVTQLAVAVNKMD--QVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGL 445

  Fly   197 HGDNML---EPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGG 258
            .|:|:.   :.|....|:|            |..|::.:|:..||.|..||..||.:.||:|..|
Mouse   446 SGENLTARSQSSDLTTWYK------------GMCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQG 498

  Fly   259 IGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRG 323
            .|....|::|.|.::.|..::..|.|.|...|.:.:|.|.:..|..||:|...:..:.:.::..|
Mouse   499 SGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVNLTLVGMDIIKINVG 563

  Fly   324 YVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTE 388
            .:....| .|.|....|.|:::|.|....|..|:..:|...|.........:...:::.:|:.|:
Mouse   564 CIFCGPK-EPIKACTRFRARILVFNIEVPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTK 627

  Fly   389 ENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVN 442
            :.||.:..|..|:|.|...:|:.:|.:::|..||||.:|....|||.||:..|:
Mouse   628 KKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYGGSTVAAGVVTEVS 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	171/444 (39%)
Hbs1l	XP_006512866.1	HBS1_N	46..113	CDD:370196
Hbs1l	XP_006512866.1	TEF1	254..680	CDD:227581	170/441 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820