DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1alpha1 and Gspt2

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001102789.1	Gene:	Gspt2 / 501582	RGDID:	1563213	Length:	632	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	168/444 - (37%)
Similarity:	259/444 - (58%)	Gaps:	17/444 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERE 68
            :|.|:|:|.|||||:||||..|.:::..|.:|:||:||:|:||:|..:.::..:|.||..:.||:
  Rat   204 KKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERD 268

  Fly    69 RGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQT 133
            :|.|:::....|||.|.:.||:|||||:.|:.|||.|.||||.|||:::|..||||.|..|.|||
  Rat   269 KGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQT 333

  Fly   134 REHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAA-VAFVPISGWH 197
            ||||:||.|.|||.|||.:||||.....:|..||||.|:::..::||:|::|.. :.|:|.||..
  Rat   334 REHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLT 398

  Fly   198 GDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTV 262
            |.|:.|.|...||:            .|...|..||::....|..|..:|||:.|.||  .:|||
  Rat   399 GANIKEQSDFCPWY------------TGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYK--DMGTV 449

  Fly   263 PVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAG 327
            .:|::|:|.:..|..:|..|...:.||..:...........||:|:...:|.:..:|:..|::..
  Rat   450 VLGKLESGSIFKGQQLVMMPNKHSVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILC 514

  Fly   328 DSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPK 392
            :.. |.......|..|::::.|...|..||..||..||.....:...:...||::||:.::..|:
  Rat   515 EPN-NLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPR 578

  Fly   393 FIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVG-VIKAVNFKD 445
            |:|.....|..|..:..:|:|.|::||.:|||.:||..:|:|:| |:|.|..||
  Rat   579 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	168/444 (38%)
Gspt2	NP_001102789.1	PAM2	54..71	CDD:284542
		TEF1	205..629	CDD:227581	165/438 (38%)
		EF1_alpha	209..425	CDD:206670	103/227 (45%)
		eRF3_II	434..514	CDD:293906	23/81 (28%)
		eRF3_C_III	521..627	CDD:294003	33/105 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820