DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and eIF5B

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001246599.1	Gene:	eIF5B / 44261	FlyBaseID:	FBgn0026259	Length:	1144	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	78/353 - (22%)
Similarity:	128/353 - (36%)	Gaps:	101/353 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVVIGHVDSGKSTTTGHLIYKCGGIDK-RTIEKFEKEA----QEMGKGSFKYAWVLDKLKAERER 69
            :.|:||||:||:..          :|| |.....:.||    |::|..:.....:.::.|..:
  Fly   558 VCVLGHVDTGKTKI----------LDKLRRTHVQDSEAGGITQQIGATNVPIEAIKEQTKYVK-- 610

  Fly    70 GITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTR 134
                  |...||.....:.|||.|||..|......|:|..|.|:|:|     :...|:..  ||.
  Fly   611 ------AAAGFEHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVV-----DIMHGLEP--QTI 662

  Fly   135 EHALLAFTLGVKQ--LIVGVNKMD-----------------SSEPPYSEARYEEIKKEVSSYIKK 180
            |...|   |..|:  .||.:||:|                 ..:...::..:::..|:|.....:
  Fly   663 ESIQL---LKKKKCPFIVALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAE 724

  Fly   181 IGYNPAA----------VAFVPISGWHGDNMLEPSTNMPWFKGWKVERKEGNADGKTLI---DAL 232
            .|.|.|.          ::.||.|...|:.|                       |..|.   |..
  Fly   725 QGLNAALFYENTDPKTYISLVPTSAISGEGM-----------------------GNLLFMIADFC 766

  Fly   233 DAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPAN--ITTEVKSVEMH 295
            ..:|.......:.|:..:.:|..:.|:||.....:..|.|:.|..:|.|..:  |.|:::|:.|
  Fly   767 QNMLAKRLMYSEELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLM- 830

  Fly   296 HEALQEAVPGDNVGFNVKN--VSVKELR 321
                    |.......|||  |..||::
  Fly   831 --------PQPMKELRVKNAYVEYKEVK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	78/353 (22%)
eIF5B	NP_001246599.1	PRK04004	553..1129	CDD:235195	78/353 (22%)
		IF2_eIF5B	557..769	CDD:206674	56/261 (21%)
		aeIF5B_II	779..889	CDD:293904	21/81 (26%)
		IF-2	890..993	CDD:288813
		IF2_aeIF5B_IV	1016..1110	CDD:293911
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930