DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and mIF2

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	406	Identity:	98/406 - (24%)
Similarity:	147/406 - (36%)	Gaps:	136/406 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVVIGHVDSGKSTTTGHL------IYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERE 68
            :.|:||||.||:|....|      ..:.|||           .|.:|      |:.:.....||
  Fly   165 VTVMGHVDHGKTTLLDSLRGADVAAGEAGGI-----------TQHIG------AFTVTLENGER- 211

  Fly    69 RGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQT 133
                              ||.:|.|||..|......|....|..||:|||     |.|:.  .||
  Fly   212 ------------------VTFLDTPGHAAFSAMRARGAVATDIIVLVVAA-----EDGVM--AQT 251

  Fly   134 REHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGWHG 198
            ||...||....| .:||.:||:|.     .||..|:.|:|::.....:..:...|..:|||...|
  Fly   252 REVIQLAKEAQV-PIIVALNKIDK-----PEANIEKSKRELAQMGLALEEHGGDVQVIPISALKG 310

  Fly   199 DN---MLEPSTNMPWFKGWKVERKEGNADGKTLIDAL--DAILPPARPTDKALRLPLQDVYKIGG 258
            .|   :.|..:......|.|       ||...|::.:  ::...|.|                |.
  Fly   311 TNLELLAEAVSTQATLMGLK-------ADPTGLVEGIVVESKTDPRR----------------GK 352

  Fly   259 IGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHH-EALQEAVPGDNVGFNVKNVSVKELRR 322
            :.|..|.|   |.|:.|:|::...|:  .:|:.:..|: :.|.||.||.    .|:.:..:||.
  Fly   353 LSTAIVSR---GTLRKGSVLLSGLAH--AKVRGLFDHNGQPLSEAPPGT----PVEILGWRELP- 407

  Fly   323 GYVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHT---AHIACKFAE---IKEKVDR 381
              :|||.                              :|:..|   ||...|:.|   .:||::.
  Fly   408 --LAGDL------------------------------ILEVETEKKAHAVLKYREHESQQEKIES 440

  Fly   382 RSG----KTTEENPKF 393
            .|.    |..|...|:
  Fly   441 SSDEIRKKEEEHQAKY 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	98/406 (24%)
mIF2	NP_651621.2	InfB	158..689	CDD:223606	98/406 (24%)
		IF2_eIF5B	163..327	CDD:206674	57/210 (27%)
		IF2_mtIF2_II	336..431	CDD:293903	30/152 (20%)
		IF-2	482..575	CDD:288813
		mtIF2_IVc	593..680	CDD:293893
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840