DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and mEFG1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	111/501 - (22%)
Similarity:	173/501 - (34%)	Gaps:	177/501 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERE 68
            |:|. ||.:..|:||||:|.|..:::..|.|         .|..|: :|.......:|.::.||:
  Fly    40 ERIR-NIGISAHIDSGKTTLTERILFYTGRI---------AEMHEV-RGKDNVGATMDSMELERQ 93

  Fly    69 RGITIDIA----LWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISK 129
            |||||..|    |||...    :.|||.|||.||...:.......|.|||::.|..|.....::.
  Fly    94 RGITIQSAATYTLWKDTN----INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTV 154

  Fly   130 NGQTREHAL--LAFTLGVKQLIVGVNKMDS-SEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFV 191
            |.|.:.:.:  |||          :||:|. ...||         :.:|....|:.:| ||...:
  Fly   155 NRQMKRYNVPCLAF----------INKLDRLGSNPY---------RVLSQMRSKMNHN-AAFIQL 199

  Fly   192 PI--------------------SGWHG-DNMLEPSTNMPWFKGWKVERKE---------GNAD-- 224
            ||                    .|.|| |..|:   .:|  :..:||..|         .|||
  Fly   200 PIGVESNCKGIVDLVREKAIYFEGEHGMDIRLD---EIP--QDMRVESLERRQELIEHLSNADET 259

  Fly   225 -GKTLID--------------------------------------ALDAIL-------------- 236
             |:..::                                      .|||:|
  Fly   260 LGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVGTALKNKGVQPLLDAVLDYLPNPGEVENLGF 324

  Fly   237 --PPARPTDKALRLPLQD--------VYKI--GGIGTVPVGRVETGVLKPGTVVVFAPANITTEV 289
              ...:..:|.:..|.:|        .:|:  |..|.:...|...|||:.|..:..|..|....:
  Fly   325 IEKEGQDPEKVVLNPARDGKDPFVGLAFKLEAGRFGQLTYLRCYQGVLRKGDNIFNARTNKKVRI 389

  Fly   290 -KSVEMHH---EALQEAVPGDNVG-FNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNH 349
             :.|.:|.   |.:.|...||... |.|...|          ||:....||.  :.:.:.|.:..
  Fly   390 ARLVRLHSNQMEDVNEVYAGDIFALFGVDCAS----------GDTFTTNPKN--NLSMESIFVPE 442

  Fly   350 PGQIANGYTPVLDCHTAHIACKFAEIKEK--VDRRSGKTTEENPKF 393
            |              ...:|.|....|::  ..:...:.|:|:|.|
  Fly   443 P--------------VVSMAIKPNNTKDRDNFSKAIARFTKEDPTF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	111/501 (22%)
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	74/310 (24%)
		PRK12740	48..727	CDD:237186	107/492 (22%)
		mtEFG1_II_like	347..427	CDD:293908	21/89 (24%)
		EFG_III	441..516	CDD:293919	8/48 (17%)
		EFG_mtEFG1_IV	519..636	CDD:238715
		mtEFG1_C	641..718	CDD:239764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930