DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and Hbs1l

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_038962831.1	Gene:	Hbs1l / 293408	RGDID:	1308509	Length:	682	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	170/443 - (38%)
Similarity:	259/443 - (58%)	Gaps:	20/443 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAE 66
            ||:.  :|:|||||||:||||..||::|..|.::|||:.|:|:|:::.||.||.||||||:...|
  Rat   255 GKQL--LNLVVIGHVDAGKSTLMGHMLYLLGNVNKRTMHKYEQESKKAGKASFAYAWVLDETGEE 317

  Fly    67 RERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNG 131
            ||||:|:|:.:.||||....||::|||||:|||.|||||.:|||.|||:|.|..||||||....|
  Rat   318 RERGVTMDVGMTKFETTTKVVTLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGG 382

  Fly   132 QTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGW 196
            |||||.||..:|||.||.|.|||||  :..:.:.|::||..::..::|:.|:..:.|||:|.||.
  Rat   383 QTREHGLLVRSLGVTQLAVAVNKMD--QVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGL 445

  Fly   197 HGDNMLEPSTN---MPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGG 258
            .|:|:...|.:   ..|:|            |..|::.:|:..||.|..||..||.:.||:|..|
  Rat   446 SGENLTSRSQSSDLTKWYK------------GLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQG 498

  Fly   259 IGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRG 323
            .|....|::|.|.::.|..::..|.|.|...|.:.:|.|.:..|..||:|...:..:.:.::..|
  Rat   499 SGFCVTGKIEAGYVQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVG 563

  Fly   324 YVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTE 388
            .:....| .|.|....|.|::::.|....|..|:..:|...|.........:...:::.:|:.|:
  Rat   564 CIFCGPK-EPIKACTRFRARILIFNIEVPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTK 627

  Fly   389 ENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAV 441
            :.||.:..|..|:|.|...:|:.:|.:::|..||||.:|....|||.||:..:
  Rat   628 KKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYGGSTVAAGVVTEI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	170/443 (38%)
Hbs1l	XP_038962831.1	HBS1_N	45..119	CDD:401037
Hbs1l	XP_038962831.1	TEF1	254..682	CDD:227581	170/443 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820