DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1alpha1 and Eef1a2

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_036792.2	Gene:	Eef1a2 / 24799	RGDID:	3781	Length:	463	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	391/463 - (84%)
Similarity:	423/463 - (91%)	Gaps:	0/463 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKA 65
            |||||.||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
  Rat     1 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKA 65

  Fly    66 ERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKN 130
            ||||||||||:||||||.|||:||||||||||||||||||||||||||||||||.||||||||||
  Rat    66 ERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKN 130

  Fly   131 GQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISG 195
            ||||||||||:||||||||||||||||:||.|||.||:||.||||:||||||||||.|.||||||
  Rat   131 GQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISG 195

  Fly   196 WHGDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIG 260
            ||||||||||.|||||||||||||||||.|.:|::|||.||||.|||||.|||||||||||||||
  Rat   196 WHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIG 260

  Fly   261 TVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYV 325
            ||||||||||:|:||.||.|||.||||||||||||||||.||:|||||||||||||||::|||.|
  Rat   261 TVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNV 325

  Fly   326 AGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEEN 390
            .|||||:||:.||.||:|||:|||||||:.||:||:|||||||||||||:|||:||||||..|:|
  Rat   326 CGDSKADPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDN 390

  Fly   391 PKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAA 455
            ||.:||||||||.:||.||:|||:|.::|||||||||||||||||||||.|..|....|||||:|
  Rat   391 PKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSA 455

  Fly   456 EKATKGKK 463
            :||.|..|
  Rat   456 QKAQKAGK 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	387/455 (85%)
Eef1a2	NP_036792.2	PTZ00141	1..460	CDD:185474	389/458 (85%)
		G1. /evidence=ECO:0000250	14..21		6/6 (100%)
		G2. /evidence=ECO:0000250	70..74		3/3 (100%)
		G3. /evidence=ECO:0000250	91..94		2/2 (100%)
		G4. /evidence=ECO:0000250	153..156		2/2 (100%)
		G5. /evidence=ECO:0000250	194..196		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..463		10/18 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	436	1.000	Domainoid score	I547
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	811	1.000	Inparanoid score	I455
OMA	1	1.010	-	-		QHG62187
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	1	1.000	-	-		mtm8922
orthoMCL	1	0.900	-	-		OOG6_100227
Panther	1	1.100	-	-	O	PTHR23115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840