DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and Gspt1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001003978.1	Gene:	Gspt1 / 24420	RGDID:	2751	Length:	636	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	173/444 - (38%)
Similarity:	258/444 - (58%)	Gaps:	17/444 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERE 68
            :|.|:|:|.|||||:||||..|.::|..|.:||||:||:|:||:|..:.::..:|.||..:.||:
  Rat   208 KKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERD 272

  Fly    69 RGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQT 133
            :|.|:::....|||.|.:.||:|||||:.|:.|||.|.||||.|||:::|..||||.|..|.|||
  Rat   273 KGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQT 337

  Fly   134 REHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAA-VAFVPISGWH 197
            ||||:||.|.|||.|||.:||||.....:|..||||.|:::..::||:|:||.. :.|:|.||..
  Rat   338 REHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLIPFLKKVGFNPKKDIHFMPCSGLT 402

  Fly   198 GDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTV 262
            |.|:.|.|...||:            .|...|..||.:....|..|..:|||:.|.||  .:|||
  Rat   403 GANLKEQSDFCPWY------------IGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYK--DMGTV 453

  Fly   263 PVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAG 327
            .:|::|:|.:..|..:|..|.....||..:...........||:|:...:|.:..:|:..|::..
  Rat   454 VLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILC 518

  Fly   328 DSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPK 392
            |.. |.......|.||::::.|...|..||..||..||.....:...:...||::||:.::..|:
  Rat   519 DLN-NLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPR 582

  Fly   393 FIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVG-VIKAVNFKD 445
            |:|.....|..|..:..:|:|.|::||.:|||.:||..:|:|:| |:|.|..||
  Rat   583 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	173/444 (39%)
Gspt1	NP_001003978.1	PAM2	62..79	CDD:284542
		TEF1	209..633	CDD:227581	170/438 (39%)
		EF1_alpha	213..429	CDD:206670	106/227 (47%)
		eRF3_II	438..519	CDD:293906	23/82 (28%)
		eRF3_C_III	525..631	CDD:294003	34/105 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820