DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1alpha1 and cgp-1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_503137.1	Gene:	cgp-1 / 178540	WormBaseID:	WBGene00000480	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	119/502 - (23%)
Similarity:	204/502 - (40%)	Gaps:	103/502 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAER 67
            |:.|...:.|:|:||:||||..|.|.:               .|.:.|:|:.:..  |.:.|.|.
Worm   136 KDFIEARVAVVGNVDAGKSTLLGVLTH---------------SALDDGRGAARTK--LFRHKHEF 183

  Fly    68 ERGITIDIA--LWKFET------------------------AKYYVTIIDAPGHRDFIKNMITGT 106
            |.|.|..:.  :..|:.                        || .||.||..||..::|..|.|.
Worm   184 ESGRTSSVGNDILGFDVHGNIVNKPDPHNHNLDWVQIGSDCAK-LVTFIDLAGHEKYLKTTIFGM 247

  Fly   107 S--QADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEE 169
            :  ..|..:|::.|..|..       |.|:||..||.:|.|...:| |.|:|.......|...:.
Worm   248 TGHMPDYTMLMIGANMGII-------GTTKEHLSLALSLHVPVYLV-VTKIDMCPANILEETMKN 304

  Fly   170 IKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTNMPWFKG---WKVERKEGNADGKTLIDA 231
            |.:.|.| .||:          ||...:.|:::..:.|.|..|.   ::|...||.  ...|:..
Worm   305 ITRLVRS-AKKL----------PILVRNMDDVVHAAVNFPSKKVCPIFQVSNVEGT--NLPLLRQ 356

  Fly   232 LDAILPPARPTDK--ALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPAN----ITTEVK 290
            ...|:|..|..::  .....:.|:|.:.|:||:..|.:.:|.::...:::..|.:    :...:|
Worm   357 FLNIVPLRRQLNENDPAHFQIDDIYWVDGVGTIASGTLLSGTIRLNDILLLGPTSNGDFMPIPIK 421

  Fly   291 SVEMHHEALQEAVP--GDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNHPGQI 353
            |:  |.:.:...:.  |.:..|.:|.:..|::|:|.|..|.|..|..... |.|:::||:||..|
Worm   422 SI--HRKRMPVGIVKCGQSASFALKKIPKKDVRKGMVLVDPKVKPVASMV-FEAEILVLHHPTTI 483

  Fly   354 ANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKFIKSGDAAIVNLVPSKPLCVEAFQEF 418
            ...|..:|...:.........:.::| .|:|...:...|||:..:..       :|.....|:|
Worm   484 KPNYQAMLHIGSVRQTATLVSMGKEV-LRTGDRDKVQFKFIRQPEYI-------RPGTKMVFRE- 539

  Fly   419 PPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAAEKATK--GKK 463
               ||        |.|||.:.:|..:::...:..|..:...|  |||
Worm   540 ---GR--------TKAVGTVSSVVPQESLAQQRAKQKDGRQKQYGKK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	115/492 (23%)
cgp-1	NP_503137.1	GTPBP1	44..552	CDD:227583	113/477 (24%)
		GTPBP1_like	142..364	CDD:206728	65/260 (25%)
		GTPBP_II	373..459	CDD:293895	18/87 (21%)
		GTPBP_III	465..551	CDD:294007	24/106 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910