DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and efsc-1

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_493275.1	Gene:	efsc-1 / 173172	WormBaseID:	WBGene00008133	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	119/531 - (22%)
Similarity:	190/531 - (35%)	Gaps:	160/531 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 INIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGIT 72
            :|:.::|||||||:|.|                   :...|:|..|...|.. .....:..|..|
Worm    14 LNLGILGHVDSGKTTLT-------------------RRIAELGSTSAFDAHA-TSTTTDGIRRNT 58

  Fly    73 IDIALWKFET----AKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQT 133
            :|:.   |.|    :...:.:||.|||...|:.::..::..|.|::|:     :..|||..  ||
Worm    59 LDLG---FSTMTSLSGRRLALIDCPGHSGLIRAVLAASTVFDMAIVII-----DVVAGIQP--QT 113

  Fly   134 REHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGY--NPAAVAFVPISGW 196
            .||.|||......::|:.:||.|.:|    :::..|..|:|...:|.:|.  |...|......|:
Worm   114 AEHLLLASKFCPNRVIIVLNKCDLAE----KSKISESAKKVRKGLKSMGVDENSPIVEMSLADGY 174

  Fly   197 HGDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGT 261
            ..:.||:   |:                 |..|::  .|..|.|..:....:.:...:.|.|.||
Worm   175 FKEEMLQ---NL-----------------KLAIES--RIFEPKRDEEGEFLIAIDHCFAIKGQGT 217

  Fly   262 VPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVA 326
            |..|.|..|||:..|.:.|...|....||::|...:.:.:...|....|.|.....:......:.
Worm   218 VLTGTVIRGVLRLNTEIEFPALNEKRRVKTLETWKQRVGQVAAGARAAFLVAPSFDEHRFSRCIC 282

  Fly   327 GDSKANPPKGAADFTAQVIVLNHPGQI----ANGYTPVLDCHTAHIA---------CKFAEIKEK 378
            |      |.|....|..|:....|.|.    .|..:.:      |:|         |:|  :|||
Worm   283 G------PLGTLKSTKFVLATVEPIQFFRKSINSKSKI------HVAVAFETVMAECQF--LKEK 333

  Fly   379 VDRRSGKTTEENPKF------------IKSGDAAIVNLVP---SKPLCVEAFQEFPPLG-RFAV- 426
                      ||.:|            :.|.:.:|  .:|   |.|......::.|..| |||.
Worm   334 ----------ENGEFEMLPSLLAPCQVLFSFEKSI--FLPENYSNPFMAARLEQQPGSGCRFAFS 386

  Fly   427 -------------------------------RDMRQTVAVGVIKA-VNFK--------DASG--G 449
                                           :|....:..|:.|| .||.        .:||  |
Worm   387 GIFSQILPENGKNLPPRFTRKCRKGHVERVEKDGFSAICTGMFKAETNFDVFRGFQICTSSGPRG 451

  Fly   450 KVTKAAEKATK 460
            |:..|..|:.|
Worm   452 KIEGAFGKSGK 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	117/526 (22%)
efsc-1	NP_493275.1	SelB	14..493	CDD:225815	119/531 (22%)
efsc-1	NP_493275.1	P-loop_NTPase	15..189	CDD:393306	56/227 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910