DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha1 and K07A12.4

DIOPT Version :9

Sequence 1:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001021555.2	Gene:	K07A12.4 / 172672	WormBaseID:	WBGene00010622	Length:	610	Species:	Caenorhabditis elegans

Alignment Length:	444	Identity:	161/444 - (36%)
Similarity:	252/444 - (56%)	Gaps:	28/444 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERE 68
            :|..||::|:||||:||||..|||::....:|.|||:||:.||...||.||.||||||:.:.|||
Worm   185 DKDLINLIVVGHVDAGKSTLMGHLLHDLEVVDSRTIDKFKHEAARNGKASFAYAWVLDETEEERE 249

  Fly    69 RGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQT 133
            ||:|:||....|||:...:.::|||||:|||.||||||||||.|:|:|.|.|||||.|....|||
Worm   250 RGVTMDIGRTSFETSHRRIVLLDAPGHKDFISNMITGTSQADAAILVVNATTGEFETGFENGGQT 314

  Fly   134 REHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYI-KKIGYNPAAVAFVPISGWH 197
            :|||||..:|||.||||.|||:|:.:  :|:.|::|||..:|.:: ::.|::..  .|||:||:.
Worm   315 KEHALLLRSLGVTQLIVAVNKLDTVD--WSQDRFDEIKNNLSVFLTRQAGFSKP--KFVPVSGFT 375

  Fly   198 GDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTV 262
            |:|::: ...:.|:            ||..|::.:|:.:.|..|:|..||:.:.||.|:.....|
Worm   376 GENLIK-RMELDWY------------DGPCLLELIDSFVAPQPPSDGPLRIGISDVLKVASNQLV 427

  Fly   263 PVGRVETG-VLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKE-LRRGYV 325
            ..|::|:| |.|...|.:.:.....| ||.. .:::..:....||.:...::.....| ::.|.|
Worm   428 VSGKIESGEVEKDDKVYIMSSVTAAT-VKEC-ANNDGSRHCFAGDYILLTLQGTFEPESIQTGSV 490

  Fly   326 ---AGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTT 387
               ||.....|.|   .|..:::.......|..|....|..|:..:.|.|..:...:::.:|:..
Worm   491 VVRAGPDTLIPSK---KFEVRLVAFEIAMPIIKGAKAELYAHSLCVPCTFTNLLYTINKSNGEIL 552

  Fly   388 EENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAV 441
            ::.|:||..|.:|:|.:.....:.:|.|.....|||...|....|:|.|:::.|
Worm   553 KKGPRFIAKGASAVVEIETEYDIAIETFTSCRALGRVTFRAGGNTIAAGIVEKV 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	161/444 (36%)
K07A12.4	NP_001021555.2	TEF1	176..606	CDD:227581	160/442 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920