Protein Alignment eEF1alpha1 and HBS1L

DIOPT Version :10

• Sequence 1: NP_477375.1
• Gene: eEF1alpha1 / 36271
• FlyBaseID: FBgn0284245
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_006611.1
• Gene: HBS1L / 10767
• HGNCID: 4834
• Length: 684
• Species: Homo sapiens
• Alignment Length: 179
• Identity: 40/179 - (22%)
• Similarity: 65/179 - (36%)
• Gaps: 53/179 - (29%)

  Fly   517 VWNVLQT-NAAQTAALDVGYTPGVEA---ALEAQPKVLFLLGADAGVVDKEKLPKDCFIVYQGHH 577
            :|..||. :.|...||..|..||..|   |...|.|    |.:|.|.:::.....| ...::..:
Human   220 MWATLQVLHQACEVALGSGLVPGGSALAWATHYQEK----LNSDQGCLNEWMAMSD-LESFRPPN 279

  Fly   578 GDAGAQMAHAILPGAAYTEKQGTYVNTEGRAQQTLVAVTPPGLAREDWKIL-------------- 628
            .:.|..     :||...:|::        :.:|.::|        |.|::|
Human   280 AEPGQS-----VPGWGASEQE--------QMEQAILA--------ELWQVLDASDLDSVTSKEIR 323

  Fly   629 RALSEVAGAPLPY--DTLDD-------LRTRMEDIAPHLVRYGRLEASN 668
            :||....|.||..  |.:|:       .:.|...|.|||.......|:|
Human   324 QALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHLYLGSEWNAAN 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha1	NP_477375.1	PTZ00141	1..457	CDD:185474
HBS1L	NP_006611.1	HBS1_N	54..129	CDD:462642
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..241		7/20 (35%)
		TEF1	261..684	CDD:444074	25/134 (19%)
		G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	267..274		1/7 (14%)
		G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	323..327		1/3 (33%)
		G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	344..347		0/2 (0%)
		G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	406..409
		G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	445..447
		Interaction with the exosome complex. /evidence=ECO:0000269|PubMed:28204585	546..572