DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and PDIA4

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001358173.1	Gene:	PDIA4 / 9601	HGNCID:	30167	Length:	646	Species:	Homo sapiens

Alignment Length:	464	Identity:	186/464 - (40%)
Similarity:	276/464 - (59%)	Gaps:	22/464 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEAGKET 89
            |.|..::|...:...:..||.||||||||||:|.|||.|||:.:....|||.|||||.| |..:.
Human   180 LVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDAT-AETDL 243

  Fly    90 CSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFL-DTKDTT 153
            ..::.|||||||||||:.. ..|||||||..||..||..|.||.||.:.|:.::::|| |..|..
Human   244 AKRFDVSGYPTLKIFRKGR-PYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVI 307

  Fly   154 LFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLD----KQGETDKIVLIRAPHLSNKFES 214
            :.|.|........:.:...|:..||.|:|.|:...|:..    .||:   :|:::.....:|:|.
Human   308 IIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQ---LVVMQPEKFQSKYEP 369

  Fly   215 SS----IKFEGSSESDLSTFVKENFHGLVGHR--TQDSVKDFQNPLITAYYSVDYQKNPK-GTNY 272
            .|    ::...:.:|.:..||.:....|||||  :.|:.:..:.||:..|||||:..:.: .|.:
Human   370 RSHMMDVQQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQF 434

  Fly   273 WRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFVGDKPVVLARDEKNLKYALK-DEFSVEN 336
            ||::||:|||:| .:..||||.::|:..|:.:.|....|:.......||...|:|:: :||..:.
Human   435 WRSKVLEVAKDF-PEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDT 498

  Fly   337 LQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLS 401
            |::||......:|:|.|||:|:|::|..||||.|.|.||.:|::..||.|||||||||||||:|.
Human   499 LREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLE 563

  Fly   402 PIYEELAEKLQ-DEDVAIVKMDATANDVPPE-FNVRGFPTLFWLPKDAKNKPVSYNGG-REVDDF 463
            |:|..||:|.: .:.:.|.||||||||||.: :.|.||||:::.|...|..||.:.|| |:::..
Human   564 PVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHL 628

  Fly   464 LKYIAKEAT 472
            .|:|.:.||
Human   629 SKFIEEHAT 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	186/464 (40%)
		PDI_a_PDIR	23..126	CDD:239295	52/100 (52%)
		PDI_b_ERp57	133..235	CDD:239367	25/110 (23%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	38/109 (35%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	54/104 (52%)
PDIA4	NP_001358173.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..58
		pdi_dom	67..168	CDD:273454
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	91..94
		ER_PDI_fam	177..641	CDD:273457	186/464 (40%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	556..559		2/2 (100%)
		Prevents secretion from ER	643..646
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860