Protein Alignment ERp60 and EPS1

DIOPT Version :10

• Sequence 1: NP_725084.2
• Gene: ERp60 / 36270
• FlyBaseID: FBgn0033663
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_012261.1
• Gene: EPS1 / 854812
• SGDID: S000001267
• Length: 701
• Species: Saccharomyces cerevisiae
• Alignment Length: 512
• Identity: 106/512 - (20%)
• Similarity: 179/512 - (34%)
• Gaps: 176/512 - (34%)

  Fly    43 LVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKL--AKVDCTEAGKETCSKYSVSGYPTLKIFR 105
            ::.||:|:|.|||.|.|.:.:..|..|::...:.:  ::|:|.|:. :.|...::..:|.:::
Yeast    52 IIDFYSPYCPHCKHLAPVWMETWEEFKEESKTLNITFSQVNCIESA-DLCGDENIEYFPEIRL-- 113

  Fly   106 QDEVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFL 170
                   ||    .||..|..       ::|.||...|..|...:........:|.||.
Yeast   114 -------YN----PSGYIKSF-------TETPRTKESLIAFARRESMDPNNLDTDLDSA------ 154

  Fly   171 KFADKNREKYRFGHSSEKEVLDKQGETDKIVLIRA----PHLSNKFESSSIKFEGSSESDLSTFV 231
                |:..:|..|.             |.:.||..    |||.:.:.:..:|   :|:..|.
Yeast   155 ----KSESQYLEGF-------------DFLELIAGKATRPHLVSFWPTKDMK---NSDDSLE--- 196

  Fly   232 KENFHGLVGHRTQDSVKDFQN--PLITAYYSVD--------YQKNP------------KGTNYWR 274
                     .:..|...:||.  .:|:...:||        .:.||            |.||:..
Yeast   197 ---------FKNCDKCHEFQRTWKIISRQLAVDDINTGHVNCESNPTICEELGFGDLVKITNHRA 252

  Fly   275 NRVLKVAKEFVGQINFAIASKDDFQHELNEY--GYDFVGDKPVVLARDE-KNLKYALKDEFSVEN 336
            :|..||          |:...:...:.|.:|  ||....|..|..||.. .|.|:....|..:|.
Yeast   253 DREPKV----------ALVLPNKTSNNLFDYPNGYSAKSDGYVDFARRTFTNSKFPNITEGELEK 307

  Fly   337 LQ----DFVE---KLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWC 394
            ..    ||::   ::..|::......:|         :..|.::||.|      :.|||
Yeast   308 KANRDIDFLQERGRVTNNDIHLVFSYDP---------ETVVIEDFDIL------EYLIE------ 351

  Fly   395 GHCKKLSPIYEELAEKLQDEDVAIV------------KMDATANDVPPEFN--------VRGFPT 439
             ...|:..||      |...|..::            |::..|:.....||        |...||
Yeast   352 -PLSKIPNIY------LHQIDKNLINLSRNLFGRMYEKINYDASQTQKVFNKEYFTMNTVTQLPT 409

  Fly   440 LFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKGFD-------RSGKPKKTEL 489
             |::.||  ..|:||       .|..|    :|||::..|       :...|..||:
Yeast   410 -FFMFKD--GDPISY-------VFPGY----STTEMRNIDAIMDWVKKYSNPLVTEV 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	102/493 (21%)
EPS1	NP_012261.1	Thioredoxin	33..139	CDD:395038	26/107 (24%)
		PTZ00102	<404..>472	CDD:240266	18/63 (29%)