DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and MPD1

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_014931.3	Gene:	MPD1 / 854462	SGDID:	S000005814	Length:	318	Species:	Saccharomyces cerevisiae

Alignment Length:	317	Identity:	78/317 - (24%)
Similarity:	136/317 - (42%)	Gaps:	81/317 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLGFIAISSGAEQD-------VLELGDDDFATTL-KQHETTLVMFYAPWCGHCKRLKPEYAKAA 65
            ||||...::....|:       :.||....|...: ..:.|:||.||||||||||:|...:.|||
Yeast     9 LLLGLFIMNEVKAQNFYDSDPHISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFRKAA 73

  Fly    66 EIVKDDDPPIKLAKVDC-TEAGKETCSKYSVSGYPTLKIFRQDEV-----------------SQD 112
               |..|..:::|.|:| ....|..|:||.|:|:|||.:||..::                 ::.
Yeast    74 ---KRLDGVVQVAAVNCDLNKNKALCAKYDVNGFPTLMVFRPPKIDLSKPIDNAKKSFSAHANEV 135

  Fly   113 YNGPR--------EASGIAKYMR--AQVGPASKTVRTVAELKKFLDTKDTTL------------- 154
            |:|.|        ..|.|..|::  .::......:|...:|...|.:|...:
Yeast   136 YSGARTLAPIVDFSLSRIRSYVKKFVRIDTLGSLLRKSPKLSVVLFSKQDKISPVYKSIALDWLG 200

  Fly   155 -FGYFSDSDSKLAKI--FLKFADKNREKYRFGHSSEKEVLDKQGETDKIVLIRAPHLSNKFESSS 216
             |.::|.|:.||.::  .....:|..|.:::    .::|:.:|.::||..|:       .|::..
Yeast   201 KFDFYSISNKKLKQLTDMNPTYEKTPEIFKY----LQKVIPEQRQSDKSKLV-------VFDADK 254

  Fly   217 IKF---EGSS--ESDLSTFVKENFHGLVGHRTQDSVKDFQNPLITAYYSVDYQKNPK 268
            .||   ||:|  ::|:|.|:::.|          |:...:.|.......:.|.|..|
Yeast   255 DKFWEYEGNSINKNDISKFLRDTF----------SITPNEGPFSRRSEYIAYLKTGK 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	73/303 (24%)
		PDI_a_PDIR	23..126	CDD:239295	41/136 (30%)
		PDI_b_ERp57	133..235	CDD:239367	25/122 (20%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	5/30 (17%)
		PDI_a_PDI_a'_C	365..467	CDD:239293
MPD1	NP_014931.3	ER_PDI_fam	30..>275	CDD:273457	67/258 (26%)
MPD1	NP_014931.3	PDI_a_MPD1_like	30..150	CDD:239300	39/122 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910