Protein Alignment ERp60 and EUG1

DIOPT Version :9

• Sequence 1: NP_725084.2
• Gene: ERp60 / 36270
• FlyBaseID: FBgn0033663
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_010806.1
• Gene: EUG1 / 852130
• SGDID: S000002926
• Length: 517
• Species: Saccharomyces cerevisiae
• Alignment Length: 512
• Identity: 146/512 - (28%)
• Similarity: 246/512 - (48%)
• Gaps: 83/512 - (16%)

  Fly    23 DVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEAGK 87
            |:|.|.:..|.:.::.|...||.|:||||.|.:.|:|...:||.|:|:.:.|:  .::|| ||..
Yeast    34 DLLVLTEKKFKSFIESHPLVLVEFFAPWCLHSQILRPHLEEAASILKEHNVPV--VQIDC-EANS 95

  Fly    88 ETCSKYSVSGYPTLKIFRQDEV--SQDYNGPREASGIAKYMRAQVGPASKT-VRTVAELKKFLDT 149
            ..|.:.:::.|||||||:...:  .|.|.|.:....|.:|| .|:..||.. :.:..|::.:|:
Yeast    96 MVCLQQTINTYPTLKIFKNGRIFDGQVYRGVKITDEITQYM-IQLYEASVIYLNSEDEIQPYLE- 158

  Fly   150 KDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQGETDKIVLIRAPHLSNKFES 214
             :.||....:...:.|.:.:.:.|....|.|.|     ..:||.:   ||.:.|   ||.|..|
Yeast   159 -NATLPVVINRGLTGLNETYQEVALDLAEDYVF-----LSLLDSE---DKSLSI---HLPNTTE- 210

  Fly   215 SSIKFEGSSESDLSTFVKENFHGLVGHR---TQ-------DSVKDFQNPLITAYYSVD------- 262
             .|.|:|:.:|            |||:.   ||       ....|.:..|...|.|.:
Yeast   211 -PILFDGNVDS------------LVGNSVALTQWLKVVILPYFTDIEPDLFPKYISSNLPLAYFF 262

  Fly   263 YQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFVGDK---PVVLARDE-KN 323
            |....:..:| .:...::.||..|||||...:...|.|.:.     |:..:   |:....:. .|
Yeast   263 YTSEEELEDY-TDLFTQLGKENRGQINFIALNSTMFPHHVR-----FLNMREQFPLFAIHNMINN 321

  Fly   324 LKYAL----KDEFS-VENLQ----DFVEKLLANELE----PYIKSEPIPESNDAPVKVAVAKNFD 375
            |||.|    ::|:: :|..|    |.:.:|:.:..|    |.:|||.||:...:.|...|.|..|
Yeast   322 LKYGLPQLPEEEYAKLEKPQPLDRDMIVQLVKDYREGTAKPIVKSEEIPKEQKSNVYKIVGKTHD 386

  Fly   376 DLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDED-----VAIVKMDATANDVPPEFNVR 435
            |:|.::.||.|:::||.||.|.|:.:|||||:|..|..::     :.|.::|:.|||: ..|.|.
Yeast   387 DIVHDDDKDVLVKYYATWCIHSKRFAPIYEEIANVLASDESVRDKILIAEVDSGANDI-LSFPVT 450

  Fly   436 GFPTLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKG---FDRSGKPKKTEL 489
            |:||:...|....:||:.:|..|.::|..::|.:..|..:.|   :|:..:.|.:|:
Yeast   451 GYPTIALYPAGNNSKPIIFNKIRNLEDVFEFIKESGTHHIDGQAIYDKLHQAKDSEV 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	143/500 (29%)
		PDI_a_PDIR	23..126	CDD:239295	36/104 (35%)
		PDI_b_ERp57	133..235	CDD:239367	24/102 (24%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	30/135 (22%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	38/106 (36%)
EUG1	NP_010806.1	ER_PDI_fam	33..487	CDD:273457	141/490 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346123
Domainoid	1	1.000	88	1.000	Domainoid score	I1819
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I801
Isobase	1	0.950	-	0	Normalized mean entropy	S1476
OMA	1	1.010	-	-		QHG53639
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		mtm9187
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
TreeFam	1	0.960	-	-
	14	13.740