DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and PDIL1-5

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_175636.2	Gene:	PDIL1-5 / 841656	AraportID:	AT1G52260	Length:	537	Species:	Arabidopsis thaliana

Alignment Length:	501	Identity:	135/501 - (26%)
Similarity:	229/501 - (45%)	Gaps:	65/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SGAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDC 82
            |.|::.||||..|.....:..:|..:|:.|||||.....|.|.:|:||..:|:....:.:||:|.
plant    73 SKAQRIVLELNGDYTKRVIDGNEFVMVLGYAPWCARSAELMPRFAEAATALKEIGSSVLMAKIDG 137

  Fly    83 TEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFL 147
            ....| ..|:..:.|:|||.:| .:..|..|||...|..|..:::.:.|....|:.||.|..:||
plant   138 DRYSK-IASELEIKGFPTLLLF-VNGTSLTYNGGSSAEDIVIWVQKKTGAPIITLNTVDEAPRFL 200

  Fly   148 DTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVL-----DKQGETDKIVLIRAPH 207
            |...|.:.|.|...:......|:| |.|:.::.:|..:.:.:|.     |.:.....|.|:: |.
plant   201 DKYHTFVLGLFEKFEGSEHNEFVK-AAKSDDEIQFIETRDSDVAKLLFPDLKSNNVFIGLVK-PE 263

  Fly   208 L--------SNKFESSSIKFEGSSESDLSTFVKENFHGLVGHRTQDSVKDFQNP--LITAYYSV- 261
            .        |.|.| ..::|.||::..|.|.:.|.          ::|..:.:|  |....:|.
plant   264 AERYTVYDGSYKME-KILEFLGSNKFPLFTKLTET----------NTVWVYSSPVKLQVMLFSKA 317

  Fly   262 -DYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHE------LNEYGYDFVGDKPVVLAR 319
             |:||..:...       .:|::|..::.|...   |..:|      |..:|.: .|:|.||.|.
plant   318 DDFQKLAQPLE-------DIARKFKSKLMFIYV---DITNENLAMPFLILFGIE-AGNKTVVAAF 371

  Fly   320 DEK-NLKYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGK 383
            |.. |.||.|:.:.|..::::|...|....:..|.:|||:|::.:|.:...|.|.||.||:|:.:
plant   372 DNNLNSKYLLESDPSPNSIEEFCSGLAHGTVSRYYRSEPVPDNENASIVTVVGKTFDGLVLNSRE 436

  Fly   384 DTLIEFYAPWCGHCKKLSPIYEELAEKLQD-EDVAIVKMDATANDVPPEFNVRGFPTLFWLPKDA 447
            :.|:|.:.|||.:|:.||...|:||:..:. |::...::||:||:.........:|.:.......
plant   437 NVLLEVHTPWCVNCEALSKQIEKLAKHFKGFENLVFARIDASANEHTKLQVDDKYPIILLYKSGE 501

  Fly   448 KNKPVSYNGGREVDDFLKYIAKEATTELKGFDRSGKPK----KTEL 489
            |.||:..:......|...:|.:|..          |||    |.||
plant   502 KEKPLKLSTKLSAKDIAVFINEELL----------KPKNGSAKDEL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	127/480 (26%)
		PDI_a_PDIR	23..126	CDD:239295	34/102 (33%)
		PDI_b_ERp57	133..235	CDD:239367	29/114 (25%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	26/116 (22%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	28/102 (27%)
PDIL1-5	NP_175636.2	ER_PDI_fam	79..524	CDD:273457	126/470 (27%)
		PDI_a_family	80..179	CDD:239259	33/100 (33%)
		PDI_b_family	187..286	CDD:239279	25/101 (25%)
		PDI_b'_family	303..394	CDD:239280	24/101 (24%)
		PDI_a_PDI_a'_C	418..521	CDD:239293	28/102 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830