DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and PDIL1-1

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_173594.1	Gene:	PDIL1-1 / 838779	AraportID:	AT1G21750	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	508	Identity:	179/508 - (35%)
Similarity:	283/508 - (55%)	Gaps:	48/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LAGVLLLGFIAISSGAEQD-----VLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKA 64
            |..:|:|...|.|..:|:.     ||.|...:|..|:.:|:..:|.||||||||||:|.|||.||
plant     8 LFSILVLSLCASSIRSEETETKEFVLTLDHTNFTDTINKHDFIVVEFYAPWCGHCKQLAPEYEKA 72

  Fly    65 AEIVKDDDPPIKLAKVDCT-EAGKETCSKYSVSGYPTLKIFRQ-DEVSQDYNGPREASGIAKYMR 127
            |..:..:.||:.|||:|.: |..:|..::|.|.|:||:||||. .:..|:|||||||.||..|::
plant    73 ASALSSNVPPVVLAKIDASEETNREFATQYEVQGFPTIKIFRNGGKAVQEYNGPREAEGIVTYLK 137

  Fly   128 AQVGPASKTVRTVAELKKFLDTKDTTLFGYF-----SDSDSKLAKIFLKFADKNREKYRFGHSSE 187
            .|.||||..:::..:..:.:..|...:.|.|     |:.||     |:..|:|.|.:..|.|:|:
plant   138 KQSGPASAEIKSADDASEVVSDKKVVVVGIFPKLSGSEFDS-----FMAIAEKLRSELDFAHTSD 197

  Fly   188 KEVLDKQGE---TDKIVLIRAPHLSNKFESSSIKFEGSSESDLSTFVKENFHGLVGHRTQDS--- 246
            .::|.: ||   |..:|.:..| ...:|..|. .|:|.:   |..||||:...|:....:|.
plant   198 AKLLPR-GESSVTGPVVRLFKP-FDEQFVDSK-DFDGEA---LEKFVKESSIPLITVFDKDPNNH 256

  Fly   247 ---VKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQ-INFAIASKDDFQHELNEYGY 307
               :|.|::....|...:::  ..:|....:::..:||....|| ::|.:...::.|.....:|.
plant   257 PYVIKFFESTNTKAMLFINF--TGEGAESLKSKYREVATSNKGQGLSFLLGDAENSQGAFQYFGL 319

  Fly   308 DFVGDKPVVLARDEKNLKYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAK 372
            : ....|:::.:...:.|| ||....|:.::.:|:.....::.|:.||:|||..|:.||||.|:.
plant   320 E-ESQVPLIIIQTADDKKY-LKTNVEVDQIESWVKDFKDGKIAPHKKSQPIPAENNEPVKVVVSD 382

  Fly   373 NFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQ-DEDVAIVKMDATANDVPPE-FNVR 435
            :.||:|:|:||:.|:||||||||||:||:||.:|:|...| |..|.|.|:||||||.|.: |:|:
plant   383 SLDDIVLNSGKNVLLEFYAPWCGHCQKLAPILDEVAVSYQSDSSVVIAKLDATANDFPKDTFDVK 447

  Fly   436 GFPTLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKGFDRSGKPKKTE 488
            ||||:::  |.|....|.|.|.|..:||:.::.|..       |..|:|||.|
plant   448 GFPTIYF--KSASGNVVVYEGDRTKEDFISFVDKNK-------DTVGEPKKEE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	167/479 (35%)
		PDI_a_PDIR	23..126	CDD:239295	51/109 (47%)
		PDI_b_ERp57	133..235	CDD:239367	30/109 (28%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	19/112 (17%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	54/103 (52%)
PDIL1-1	NP_173594.1	ER_PDI_fam	30..481	CDD:273457	167/467 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	115	1.000	Domainoid score	I1995
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.790