DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and PDIL1-3

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_191056.2	Gene:	PDIL1-3 / 824661	AraportID:	AT3G54960	Length:	579	Species:	Arabidopsis thaliana

Alignment Length:	486	Identity:	150/486 - (30%)
Similarity:	246/486 - (50%)	Gaps:	63/486 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEA 85
            |:||..|..|:|...:..:...:|.|||||||.|:.|.||||.||..:|.   ...|||:|.||.
plant    98 EKDVAVLTKDNFTEFVGNNSFAMVEFYAPWCGACQALTPEYAAAATELKG---LAALAKIDATEE 159

  Fly    86 GKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLDTK 150
            | :...||.:.|:||:.:|...|:.:.|.|.|...||..:::.:..|:...:.|..|.::.|..:
plant   160 G-DLAQKYEIQGFPTVFLFVDGEMRKTYEGERTKDGIVTWLKKKASPSIHNITTKEEAERVLSAE 223

  Fly   151 DTTLFGYF-----SDSDSKLAKIFLKFADKNREKYRFGHSSEKEV-----LDKQGETDKIVLIRA 205
            ...:||:.     |:|:.      |..|.:..:...|..::..::     ::.|.:...:||::
plant   224 PKLVFGFLNSLVGSESEE------LAAASRLEDDLSFYQTASPDIAKLFEIETQVKRPALVLLK- 281

  Fly   206 PHLSNKFESSSIKFEGS-SESDLSTFVKENFHGLVGHRTQD--------SVKDFQNPLITAYYSV 261
                 |.|....:|:|: :::.::.||..|...||.:.|::        |||   |.||....:.
plant   282 -----KEEEKLARFDGNFTKTAIAEFVSANKVPLVINFTREGASLIFESSVK---NQLILFAKAN 338

  Fly   262 DYQKN-PKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYG------YDFVGDKPVVL-- 317
            :.:|: |        .:.:|||.|.|:..|.....|:     .:||      :...|..|.||
plant   339 ESEKHLP--------TLREVAKSFKGKFVFVYVQMDN-----EDYGEAVSGFFGVTGAAPKVLVY 390

  Fly   318 ARDEKNLKYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNG 382
            ..:|...|:.|..|.:|.|::...|..||::|:|:.||:|:||:||..|||.|..|||::|::..
plant   391 TGNEDMRKFILDGELTVNNIKTLAEDFLADKLKPFYKSDPLPENNDGDVKVIVGNNFDEIVLDES 455

  Fly   383 KDTLIEFYAPWCGHCKKLSPIYEELAEKLQDED-VAIVKMDATANDVPPEFNVRGFPTLFWLPKD 446
            ||.|:|.||||||||:...|||.:|.:.|:..| :.:.|||.|:|: .|.....||||:.:.|..
plant   456 KDVLLEIYAPWCGHCQSFEPIYNKLGKYLKGIDSLVVAKMDGTSNE-HPRAKADGFPTILFFPGG 519

  Fly   447 AKN-KPVSYNGGREVDDFLKYIAKEATTELK 476
            .|: .|::.:..|.|.:..|::.|.|:...|
plant   520 NKSFDPIAVDVDRTVVELYKFLKKHASIPFK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	149/484 (31%)
		PDI_a_PDIR	23..126	CDD:239295	41/102 (40%)
		PDI_b_ERp57	133..235	CDD:239367	19/112 (17%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	30/122 (25%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	42/103 (41%)
PDIL1-3	NP_191056.2	ER_PDI_fam	99..553	CDD:273457	149/485 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730