DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and TMX1

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_110382.3	Gene:	TMX1 / 81542	HGNCID:	15487	Length:	280	Species:	Homo sapiens

Alignment Length:	104	Identity:	36/104 - (34%)
Similarity:	56/104 - (53%)	Gaps:	7/104 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 VKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDEDVAIVKMDATAN-DVP 429
            |:|...:|:.:|:..   |.:||||||||..|:.|.|.:|..||..:|.:|.|.|:|.|.. .:.
Human    31 VRVITDENWRELLEG---DWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAKVDVTEQPGLS 92

  Fly   430 PEFNVRGFPTLFWLPKDAKNKPVSYNGGREVDDFLKYIA 468
            ..|.:...||::.. ||.:.:  .|.|.|...||:.:|:
Human    93 GRFIITALPTIYHC-KDGEFR--RYQGPRTKKDFINFIS 128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	36/104 (35%)
		PDI_a_PDIR	23..126	CDD:239295
		PDI_b_ERp57	133..235	CDD:239367
		PDI_b'_ERp72_ERp57	239..345	CDD:239371
		PDI_a_PDI_a'_C	365..467	CDD:239293	35/101 (35%)
TMX1	NP_110382.3	PDI_a_TMX	29..129	CDD:239292	36/104 (35%)
TMX1	NP_110382.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..280
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840