DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and Tmx1

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_082615.1	Gene:	Tmx1 / 72736	MGIID:	1919986	Length:	278	Species:	Mus musculus

Alignment Length:	278	Identity:	61/278 - (21%)
Similarity:	117/278 - (42%)	Gaps:	68/278 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLLGFIAISSGAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDD 72
            ||||..:..:.|...:|..|.|::: |:|.:.| .::.||||||..|:.|:||:...||  ..:|
Mouse    15 VLLLWAVPGAHGRRNNVRVLTDENW-TSLLEGE-WMIEFYAPWCPACQNLQPEWESFAE--WGED 75

  Fly    73 PPIKLAKVDCTEAGKET--CSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKY---------- 125
            ..:|:||||.||   :|  ..::.::..|::...:..|..: |.|||.......:
Mouse    76 LEVKVAKVDVTE---QTGLSGRFIITALPSIYHCKDGEFRR-YVGPRTKKDFINFVSDKEWKNIE 136

  Fly   126 -MRAQVGPASKTVRTVA---ELKKFLDTKD---------------------TTLFG--------Y 157
             :.:..||:|..:..::   :|..::.|..                     |.|.|        :
Mouse   137 PISSWFGPSSVLMTMMSALFQLSVYIRTSHSYFVHDLGIPAWGSYLVFAFATVLSGLLLGLCMIF 201

  Fly   158 FSD--SDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQGETDKIVLIRAPHLSNKFESSSIKFE 220
            .:|  ..||..|...::|.|...::    |...:.::::.|.|:         .:..|..:...|
Mouse   202 VADCLCPSKRRKPQQQYAKKTSPEF----SQPLKKVEEEQEADE---------EDVSEEEAEDRE 253

  Fly   221 GSSESDLSTFVKENFHGL 238
            |:|::...:.:::...||
Mouse   254 GASKATSQSSIRQRCVGL 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	56/263 (21%)
		PDI_a_PDIR	23..126	CDD:239295	33/115 (29%)
		PDI_b_ERp57	133..235	CDD:239367	19/135 (14%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	61/278 (22%)
		PDI_a_PDI_a'_C	365..467	CDD:239293
Tmx1	NP_082615.1	PDI_a_TMX	30..129	CDD:239292	33/106 (31%)
Tmx1	NP_082615.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..278		11/68 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840