DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and TMX4

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_066979.2	Gene:	TMX4 / 56255	HGNCID:	25237	Length:	349	Species:	Homo sapiens

Alignment Length:	395	Identity:	88/395 - (22%)
Similarity:	132/395 - (33%)	Gaps:	129/395 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IAISSGAEQDVLELGDDDFATTLKQHETTLVM-------FYAPWCGHCKRLKPE---YAKAAEIV 68
            :|.::|.|:..|. .:......:.....||||       ||||||..|::...|   :||..||:
Human    21 VAATAGPEEAALP-PEQSRVQPMTASNWTLVMEGEWMLKFYAPWCPSCQQTDSEWEAFAKNGEIL 84

  Fly    69 KDDDPPIKLAKVD-CTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKY------- 125
            :     |.:.||| ..|.|  ...::.|:..|.. ...:|.:.:.|.||.....:..|
Human    85 Q-----ISVGKVDVIQEPG--LSGRFFVTTLPAF-FHAKDGIFRRYRGPGIFEDLQNYILEKKWQ 141

  Fly   126 ----MRAQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSS 186
                :.....|||.|:..:|              |.||.|    .||:
Human   142 SVEPLTGWKSPASLTMSGMA--------------GLFSIS----GKIW----------------- 171

  Fly   187 EKEVLDKQGETDKIVLIRAPHLSNKFE--------SSSIKFEGSSESDLSTFVKENFHGLVGHRT 243
                                ||.|.|.        .|.:.|.      ::|.|...|.|||....
Human   172 --------------------HLHNYFTVTLGIPAWCSYVFFV------IATLVFGLFMGLVLVVI 210

  Fly   244 QDSVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELN----- 303
            .:.   |..|| ..:.|...::|.:.....|...|:.|:|          .|||...|.|
Human   211 SEC---FYVPL-PRHLSERSEQNRRSEEAHRAEQLQDAEE----------EKDDSNEEENKDSLV 261

  Fly   304 --EYGYDFVGDKPVVLARDEK-NLKYALKDEFSVENLQ-----DFV--EKLLANELEPYIKSEPI 358
              |...:.:||:......:|: ||...:.:|.|..|.|     |.|  |::...|.|..|..:|.
Human   262 DDEEEKEDLGDEDEAEEEEEEDNLAAGVDEERSEANDQGPPGEDGVTREEVEPEEAEEGISEQPC 326

  Fly   359 PESND 363
            |...:
Human   327 PADTE 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	85/386 (22%)
		PDI_a_PDIR	23..126	CDD:239295	30/124 (24%)
		PDI_b_ERp57	133..235	CDD:239367	18/109 (17%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	28/120 (23%)
		PDI_a_PDI_a'_C	365..467	CDD:239293
TMX4	NP_066979.2	PDI_a_TMX	37..137	CDD:239292	29/107 (27%)
TMX4	NP_066979.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..349		28/117 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840