DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and txndc16

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	XP_685017.4	Gene:	txndc16 / 556973	ZFINID:	ZDB-GENE-100712-1	Length:	804	Species:	Danio rerio

Alignment Length:	272	Identity:	65/272 - (23%)
Similarity:	107/272 - (39%)	Gaps:	56/272 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEAG 86
            :.|.||..|.|.|.:||:|.|:|:||..|...|......|.:.||.|:|.: .::||.|||.| .
Zfish   386 EPVTELTADTFQTAIKQNEITVVLFYFKWDAVCMAFIQSYVEVAEAVEDVN-GVELAAVDCGE-W 448

  Fly    87 KETCSKYSVSGYPTLKIF-RQDEVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLD-- 148
            .:.|...:::.:||:.|: .:...:|.|.|......:.:::...:......:.:.||:..||:
Zfish   449 TDICRDQNITSFPTVLIYCPKAAAAQPYRGMMGTKSLQRFILLSLVSTPVHLSSSAEVMSFLEGD 513

  Fly   149 -------TKDTTLFGYFS----------DSDSKLAK---IFLKFADKNREKYRFGHS-------- 185
                   .....:.|.||          :..::|.:   |...||.|...|:..|.|
Zfish   514 LYRKYVYLTPVRVLGLFSSMQDMGVSSFEEAARLLRGETIIGLFAHKEAAKWVEGLSVNLPALLV 578

  Fly   186 SEKEVLDKQG-------ETDKIVLIRAPHLSNKFESSSIK---------------FEGSSESDLS 228
            |....|..|.       .||.:.||:...| .:|...:::               |.|..||..|
Zfish   579 SHGPALPHQVFSLPSSLATDHVKLIQRVEL-ERFPELTVENLPWYLELEKPLLLLFIGKEESTES 642

  Fly   229 TFVKENFHGLVG 240
            |......:.|:|
Zfish   643 TRSLAEINQLLG 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	65/271 (24%)
		PDI_a_PDIR	23..126	CDD:239295	33/103 (32%)
		PDI_b_ERp57	133..235	CDD:239367	30/153 (20%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	1/2 (50%)
		PDI_a_PDI_a'_C	365..467	CDD:239293
txndc16	XP_685017.4	PDI_a_family	389..489	CDD:239259	32/101 (32%)
txndc16	XP_685017.4	Thioredoxin_6	530..722	CDD:290560	27/126 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910