DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and pdia4

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_956073.2	Gene:	pdia4 / 554998	ZFINID:	ZDB-GENE-030131-5493	Length:	642	Species:	Danio rerio

Alignment Length:	461	Identity:	193/461 - (41%)
Similarity:	289/461 - (62%)	Gaps:	17/461 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEAGKET 89
            |.|..|:|...:...:..||.||||||||||||.|||.|||:.:.:..|||.|||||.| |..:.
Zfish   177 LVLTKDNFDDVVNNADIILVEFYAPWCGHCKRLAPEYEKAAKELSNRTPPIPLAKVDAT-AESDL 240

  Fly    90 CSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFL-DTKDTT 153
            .:::.|||||||||||:.: :.|||||||..||..||..|.||.||.|:|:.::::.| |..|..
Zfish   241 ATRFGVSGYPTLKIFRKGK-AFDYNGPREKFGIVDYMSDQAGPPSKQVQTLKQVQELLRDGDDAV 304

  Fly   154 LFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLD-KQGETDKIVLIRAPHLSNKFESSS- 216
            :.|.||..:....:|:.:..:..||.|:|.|:...:|.. .:....::|:::.....:|:||:|
Zfish   305 IVGVFSSDEDAAYEIYQEACNSLREDYKFMHTFNNDVTKFLKASPGQVVMLQPEKFRSKYESASH 369

  Fly   217 ---IKFEGSSESDLSTFVKENFHGLVGHRTQ--DSVKDFQNPLITAYYSVDYQKNPK-GTNYWRN 275
               || :.:..|::..|.|::...|||||.|  |:.:..:.||:..||.||:..:.: .|.:||:
Zfish   370 SLTIK-DSTPASEVQDFFKKHILPLVGHRKQSNDAKRYTKRPLVVVYYGVDFSFDYRVATQFWRS 433

  Fly   276 RVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFVGDKPVVLARDEKNLKYALK-DEFSVENLQD 339
            :||:|||:| .:..||||.::|:..||...|....|::..|....|...|||:: :||..:.|:.
Zfish   434 KVLEVAKDF-PEYTFAIADEEDYADELKSLGLSESGEEVNVGIVGEGGKKYAMEPEEFDSDVLRS 497

  Fly   340 FVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIY 404
            ||......:|:|.:||:|:|::|..||||.|.|.||::|:::.||.|||||||||||||||.|.|
Zfish   498 FVMAFKKGKLKPIVKSQPLPKNNKGPVKVVVGKTFDEIVMDSKKDVLIEFYAPWCGHCKKLEPDY 562

  Fly   405 EELAEKLQDE-DVAIVKMDATANDVPPE-FNVRGFPTLFWLPKDAKNKPVSYNGG-REVDDFLKY 466
            ..|.:|.::| ::.|.||||||||||.: :.|.||||:::.|.:.|..|:.:.|| |:|::|.|:
Zfish   563 ISLGKKYKNEKNLVIAKMDATANDVPHDSYKVEGFPTIYFAPSNNKQNPIKFEGGKRDVEEFSKF 627

  Fly   467 IAKEAT 472
            :.|.||
Zfish   628 VEKHAT 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	193/461 (42%)
		PDI_a_PDIR	23..126	CDD:239295	54/100 (54%)
		PDI_b_ERp57	133..235	CDD:239367	27/107 (25%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	40/109 (37%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	56/104 (54%)
pdia4	NP_956073.2	pdi_dom	64..165	CDD:273454
		ER_PDI_fam	174..640	CDD:273457	193/461 (42%)
		pdi_dom	179..280	CDD:273454	55/102 (54%)
		PDI_b_ERp72	283..389	CDD:239366	27/106 (25%)
		PDI_b'_ERp72_ERp57	394..503	CDD:239371	40/109 (37%)
		PDI_a_PDI_a'_C	523..628	CDD:239293	56/104 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4955
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860