DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and TMX3

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_061895.3	Gene:	TMX3 / 54495	HGNCID:	24718	Length:	454	Species:	Homo sapiens

Alignment Length:	421	Identity:	92/421 - (21%)
Similarity:	179/421 - (42%)	Gaps:	76/421 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLAGVLLLGFIAISSGAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIV 68
            ||...:::..:.:..|..:|:    |:.|... :..:..||.||||||||||:|:|.:.:....:
Human    11 RLCATVVVLDMVVCKGFVEDL----DESFKEN-RNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEM 70

  Fly    69 KDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPA 133
            |....|:|:.|:|.| :.....|::.|.||||:|:.:.| ::.:|.|||....|.::.....|
Human    71 KSIGSPVKVGKMDAT-SYSSIASEFGVRGYPTIKLLKGD-LAYNYRGPRTKDDIIEFAHRVSG-- 131

  Fly   134 SKTVRTVAELKKF--LDTKDTTLFGYFSDSDSKLAKIFLKFADKNRE--KYRFGHSSEKEVLDKQ 194
             ..:|.:...:.|  :..:....|.|.. .:|.|.:   |:.|...|  .|.:..|:.:||:
Human   132 -ALIRPLPSQQMFEHMQKRHRVFFVYVG-GESPLKE---KYIDAASELIVYTYFFSASEEVV--- 188

  Fly   195 GETDKIVLIRAPHLSNKFESSSIKFEGSSESDLSTFV-KENFH------GLVGHRTQDSVKDFQN 252
              .:.:.|...|.:....:.:...::...:.|||::: :|.|.      |.:.:...|:.|
Human   189 --PEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGK---- 247

  Fly   253 PLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQH-ELNEYGYDFVGDK--- 313
              :.|...:|    .|.|:....|:..:.:|..............|.| :.|:|....:.|:
Human   248 --LVALAVID----EKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLLMDELTV 306

  Fly   314 PVVLARDEKNLKYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDL- 377
            |.|:..:..|.:|.|.|. .::|::|.|: .:.|.|:..::                |:..|.:
Human   307 PTVVVLNTSNQQYFLLDR-QIKNVEDMVQ-FINNILDGTVE----------------AQGGDSIL 353

  Fly   378 -----VINNGKDTLIEFYAPWCGHCKKLSPI 403
                 ::.:.|.|::..:        |.||:
Human   354 QRLKRIVFDAKSTIVSIF--------KSSPL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	89/402 (22%)
		PDI_a_PDIR	23..126	CDD:239295	36/102 (35%)
		PDI_b_ERp57	133..235	CDD:239367	19/106 (18%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	22/109 (20%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	7/45 (16%)
TMX3	NP_061895.3	PDI_a_TMX3	27..130	CDD:239298	36/109 (33%)
		ER_PDI_fam	29..>346	CDD:273457	82/363 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..454
		Di-lysine motif	451..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156369
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840