DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and P4HB

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	XP_024306545.1	Gene:	P4HB / 5034	HGNCID:	8548	Length:	546	Species:	Homo sapiens

Alignment Length:	394	Identity:	129/394 - (32%)
Similarity:	200/394 - (50%)	Gaps:	27/394 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEA 85
            |..||.|...:||..|..|:..||.||||||||||.|.|||||||..:|.:...|:|||||.||.
Human    23 EDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEE 87

  Fly    86 GKETCSKYSVSGYPTLKIFRQDEVS--QDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLD 148
             .:...:|.|.||||:|.||..:.:  ::|...|||..|..:::.:.|||:.|:...|..:..::
Human    88 -SDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVE 151

  Fly   149 TKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDK-QGETDKIVLIRAPHLSNKF 212
            :.:..:.|:|.|.:|..||.||:.|:. .:...||.:|..:|..| |.:.|.:||.:      ||
Human   152 SSEVAVIGFFKDVESDSAKQFLQAAEA-IDDIPFGITSNSDVFSKYQLDKDGVVLFK------KF 209

  Fly   213 ESSSIKFEGS-SESDLSTFVKENFHGLVGHRTQDSVKDFQNPLITAYYSVDYQKNPKGTNYWRNR 276
            :.....|||. ::.:|..|:|.|...||...|:.:........|..:..:...|:....:...:.
Human   210 DEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSN 274

  Fly   277 VLKVAKEFVGQINFAIASKDDFQHELNEYGYDFVGDK----PVV--LARDEKNLKYALK-DEFSV 334
            ....|:.|.|:|.|.....|   |..|:...:|.|.|    |.|  :..:|:..||..: :|.:.
Human   275 FKTAAESFKGKILFIFIDSD---HTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTA 336

  Fly   335 ENLQDFVEKLLANELEPYIKSEPIPESND-APVKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCK 398
            |.:.:|..:.|..:::|::.|:.:||..| .||||.|.|||:|:..:..|:..:||    |..|.
Human   337 ERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEF----CKCCP 397

  Fly   399 KLSP 402
            ..||
Human   398 FSSP 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	128/392 (33%)
		PDI_a_PDIR	23..126	CDD:239295	50/104 (48%)
		PDI_b_ERp57	133..235	CDD:239367	29/103 (28%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	23/112 (21%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	16/38 (42%)
P4HB	XP_024306545.1	YbbN	24..394	CDD:331940	124/384 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690