DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and pdia2

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001011281.1	Gene:	pdia2 / 496734	XenbaseID:	XB-GENE-5770794	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	494	Identity:	169/494 - (34%)
Similarity:	246/494 - (49%)	Gaps:	49/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEA 85
            |.:||.|...:|...|:.::..||.|||||||||:.|.|:|||||||:||....::|||||.| .
Frog    45 EDNVLVLNKKNFDKALETYKYLLVEFYAPWCGHCQELAPKYAKAAEILKDKSEEVRLAKVDAT-V 108

  Fly    86 GKETCSKYSVSGYPTLKIFRQDEVSQ--DYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLD 148
            ..|...:::|:||||||.|:....:.  ||.|.|:..|:.|:|..::|||:..:..|...:||..
Frog   109 ESELSMEFNVNGYPTLKFFKGGNRTGHIDYGGKRDQDGLVKWMLRRLGPAAIVLDKVESAEKFTS 173

  Fly   149 TKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQGETDKIVLIRAPHLSNKFE 213
            ::::.:.|:|.:.:....|||.:.|:.| |.:.|..:.:.::.:|.|.|:..|:.    ..|..|
Frog   174 SQESPVIGFFKNPEDADIKIFYEAAELN-EDFTFALAHDAKLFEKFGVTEDTVIF----FKNSEE 233

  Fly   214 SSSIKFE---GSSESDLSTFVKENFHGLV---GHRTQDSVKDFQNP---LITAYYSVDYQKNPKG 269
            ....|.:   |..:.:||.|:|.|...||   ...|.|.:...|.|   |:....:.|.|.  ..
Frog   234 KPEFKVDEDLGLDKDELSKFLKINNIDLVTEYSAETSDKIFAAQIPNHLLLFINKTEDSQL--AL 296

  Fly   270 TNYWRNRVLKVAKEFVGQINFAIASKD-DFQHELNEYGYDFVGDKPVV-LARDEKNLKYAL-KDE 331
            ..::|    |.|..|.|:|.|.....| .|...|..:|.. ..|.|.: ....|...|||. ..|
Frog   297 LEHFR----KAATHFKGKILFVFIDSDGGFSSVLEYFGLK-SSDVPTLRFINLESVKKYAFDAPE 356

  Fly   332 FSVENLQDFVEKLLANELEPYIKSEPIPESNDA-PVKVAVAKNFDDLVINNGKDTLIEFYAPWCG 395
            .:.:.:|.|...:|...::..:.||.||...|. ||||.|.|||:::..:..|...:|||||||.
Frog   357 ITEDTIQTFCRTVLEGNVKQNLMSEEIPADWDKNPVKVLVGKNFEEVAYDESKSVFVEFYAPWCS 421

  Fly   396 HCKKLSPIYEELAEKLQD-EDVAIVKMDATANDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGGRE 459
            |||:|.|::|||.||.:| |.|.|.|||||||:: ....|||||.|.:.|.....|.:.|...|.
Frog   422 HCKELEPVWEELGEKYKDHESVIIAKMDATANEI-DGLRVRGFPNLRFFPAGPGRKMIEYTKERT 485

  Fly   460 VDDFLKYI-------------------AKEATTELKGFD 479
            |:.|..:|                   :||...|.||.|
Frog   486 VELFSAFIDSGGVLPEEQVEKDAEAEESKEVAEEDKGKD 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	167/490 (34%)
		PDI_a_PDIR	23..126	CDD:239295	48/104 (46%)
		PDI_b_ERp57	133..235	CDD:239367	25/104 (24%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	28/114 (25%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	49/102 (48%)
pdia2	NP_001011281.1	YbbN	46..502	CDD:331940	162/469 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010