DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and pdia7

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_998070.1	Gene:	pdia7 / 405841	ZFINID:	ZDB-GENE-040426-2238	Length:	488	Species:	Danio rerio

Alignment Length:	484	Identity:	229/484 - (47%)
Similarity:	315/484 - (65%)	Gaps:	18/484 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLAGVLLLGFIAISSGAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIV 68
            ||...::...:.:......|||||||.||..:...|:|.||.|:|||||||:||.|||..||..:
Zfish     2 RLPCFIICAVLTVWLAEGSDVLELGDSDFDRSAGMHDTLLVEFFAPWCGHCQRLAPEYEAAATKL 66

  Fly    69 KDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPA 133
            |.   .:.||||||| ...|||.::.|:|||||||||..|.|..|:|||.|.||..||:.|.||:
Zfish    67 KG---TLALAKVDCT-VNSETCERFGVNGYPTLKIFRNGEESGAYDGPRTADGIVSYMKKQAGPS 127

  Fly   134 SKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQG-ET 197
            |..:...|:|..|:|..:.::.|:||..||.....|||.:...|:.|||.||::.....|.| :.
Zfish   128 SVALLKEADLDGFVDNYEASVVGFFSGEDSAQLAEFLKASSALRDSYRFAHSTDVGAGLKYGVDG 192

  Fly   198 DKIVLIRAPHLSNKFESSSIKF-EGSSESDLSTFVKENFHGLVGHRT---QDSVKDFQNPLITAY 258
            :.::|.|.|.||:|||.:.:|: |..|.|.|..|||:|..||..|.|   :|:|:  ::.|:||:
Zfish   193 ECVLLFRPPRLSSKFEDNVVKYTEHLSVSSLHKFVKDNILGLCPHMTMENRDTVR--ESDLLTAF 255

  Fly   259 YSVDYQKNPKGTNYWRNRVLKVAKEFVGQ-INFAIASKDDFQHEL-NEYGYDFV--GDKPVVLAR 319
            ::|||.:|||||||||||::|||.:|..: :.||:|.:.:||.|| .|:|....  ||.|:|..|
Zfish   256 FNVDYLRNPKGTNYWRNRIMKVATQFQDRGLTFAVADRQEFQDELEEEFGVSSSEGGDVPLVTIR 320

  Fly   320 DEKNLKYALKDEFSVE--NLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNG 382
            .....||::::||:.:  :|:.|:|...|..|:.|:||||||||||.||||.||..||.:|.:..
Zfish   321 TRAGQKYSMQEEFTRDGKSLEKFLEDYFAKRLKRYVKSEPIPESNDGPVKVLVADTFDAIVNDPE 385

  Fly   383 KDTLIEFYAPWCGHCKKLSPIYEELAEKLQ-DEDVAIVKMDATANDVPPEFNVRGFPTLFWLPKD 446
            ||.|:|||||||||||.|.|.|:||.|||. :.::.|.|||||||||||.::|:||||::::|..
Zfish   386 KDVLVEFYAPWCGHCKNLEPKYKELGEKLSGNPNIVIAKMDATANDVPPNYDVQGFPTIYFVPSG 450

  Fly   447 AKNKPVSYNGGREVDDFLKYIAKEATTEL 475
            .|::|..|.|||||:||:.|:.||||..|
Zfish   451 QKDQPRRYEGGREVNDFITYLKKEATNPL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	227/465 (49%)
		PDI_a_PDIR	23..126	CDD:239295	58/102 (57%)
		PDI_b_ERp57	133..235	CDD:239367	37/103 (36%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	46/114 (40%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	59/102 (58%)
pdia7	NP_998070.1	ER_PDI_fam	20..483	CDD:273457	227/466 (49%)
		Thioredoxin_like	25..124	CDD:294274	56/102 (55%)
		PDI_b_ERp57	127..231	CDD:239367	37/103 (36%)
		PDI_b'_ERp72_ERp57	235..348	CDD:239371	46/114 (40%)
		PDI_a_PDI_a'_C	368..471	CDD:239293	59/102 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592002
Domainoid	1	1.000	147	1.000	Domainoid score	I4447
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1689
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		otm26283
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770