DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and pdia3

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_989329.1	Gene:	pdia3 / 394954	XenbaseID:	XB-GENE-976328	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	499	Identity:	252/499 - (50%)
Similarity:	327/499 - (65%)	Gaps:	20/499 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LAGVLLLGFIAISSGAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVK 69
            |....||...|.:..|..|||:|.||:|.:|:.||...||.|:||||||||:|.|||..||..:|
Frog     6 LGAFFLLAVTAGTQAAGSDVLDLTDDNFESTVSQHSILLVEFFAPWCGHCKKLAPEYEIAATKLK 70

  Fly    70 DDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPAS 134
            .   .:.||||||| |...||:||.|||||||||||..|.|..|:|||.|.||...|:.|.||||
Frog    71 G---TLSLAKVDCT-ANSNTCNKYGVSGYPTLKIFRDGEDSGSYDGPRTADGIVSTMKKQAGPAS 131

  Fly   135 KTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDK-QGETD 198
            ..:|:|.|.:||:..||.::.|:|.|..|.....|||.|:..|:.|||.|:.|||::|| ....:
Frog   132 VDLRSVGEFEKFISDKDASVVGFFRDLYSGPHSEFLKAANTLRDNYRFAHTDEKELVDKYDSNGE 196

  Fly   199 KIVLIRAPHLSNKFESSSIKF---EGSSESDLSTFVKENFHGLVGHRTQDSVKDF--QNPLITAY 258
            ..||.|..||:||||.||:.|   |..:.|.:..|:::|..||..|.|:|: ||.  ...|:.||
Frog   197 GFVLFRPQHLANKFEDSSVTFPADEKITSSKIKKFIQDNIFGLCPHLTEDN-KDLIQGKDLLVAY 260

  Fly   259 YSVDYQKNPKGTNYWRNRVLKVAKEFVG---QINFAIASKDDFQHELNEYGYDF-VGDKPVVLAR 319
            |.|||:||.||||||||||:||||.||.   ::|||:|::..|.||:.|:|.|. .|:.|||..:
Frog   261 YDVDYEKNVKGTNYWRNRVMKVAKSFVDAGKKLNFAVANRKAFGHEVTEFGLDAGTGELPVVGIK 325

  Fly   320 DEKNLKYALKDEFSVEN--LQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNG 382
            ..|..|||:::|||.:.  |:.|::.....:|:.|:|||.||||||.||||.||:|||::|.::.
Frog   326 TAKGEKYAMQEEFSRDGKALERFLQDYFDGKLKRYMKSEAIPESNDGPVKVVVAENFDEIVNDDS 390

  Fly   383 KDTLIEFYAPWCGHCKKLSPIYEELAEKLQDE-DVAIVKMDATANDVPPEFNVRGFPTLFWLPKD 446
            ||.|||||||||||||.|.|.|:||.|||.|: ::.|.||||||||||.::.||||||:::.|..
Frog   391 KDVLIEFYAPWCGHCKNLEPKYKELGEKLGDDPNIVIAKMDATANDVPSQYEVRGFPTIYFTPAG 455

  Fly   447 AKNKPVSYNGGREVDDFLKYIAKEATTE--LKGFDRSGKPKKTE 488
            :|.||..|.|||||.|||.|:.||||..  :|..::..|.||.|
Frog   456 SKQKPKRYEGGREVSDFLSYLKKEATNPPVVKEDEKPKKKKKKE 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	243/470 (52%)
		PDI_a_PDIR	23..126	CDD:239295	60/102 (59%)
		PDI_b_ERp57	133..235	CDD:239367	42/105 (40%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	53/113 (47%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	64/102 (63%)
pdia3	NP_989329.1	ER_PDI_fam	23..483	CDD:273457	242/464 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4406
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68454
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1631
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		oto103550
Panther	1	1.100	-	-	LDO	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080