Protein Alignment ERp60 and txndc5

DIOPT Version :9

• Sequence 1: NP_725084.2
• Gene: ERp60 / 36270
• FlyBaseID: FBgn0033663
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_989186.1
• Gene: txndc5 / 394794
• XenbaseID: XB-GENE-490945
• Length: 405
• Species: Xenopus tropicalis
• Alignment Length: 494
• Identity: 126/494 - (25%)
• Similarity: 198/494 - (40%)
• Gaps: 118/494 - (23%)

  Fly     6 AGVLLLGFIAISSGAEQDVLELGDDD-----------FATTLKQHETTLVMFYAPWCGHCKRLKP 59
            :.:||...:|..||...:  |..|:|           |...:|| |...:||:|||||||:||:|
 Frog     6 SALLLCAVLARVSGEPWE--EGADEDPHKKNLYTADMFDHAIKQ-EPHFIMFFAPWCGHCQRLQP 67

  Fly    60 EYAKAAE-IVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIA 123
            .:.:..: ..:....|..:|||||| ....||:::.|.||||||:||..:.:..|.|||:...:.
 Frog    68 TWNELGDKYNRMSKTPAYIAKVDCT-TDMPTCTEHGVRGYPTLKLFRPGQEAVKYQGPRDLQSLE 131

  Fly   124 KYM---------RAQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREK 179
            .:|         :.:|....:....|.|||:.|.......|.......:...|.|..:.
 Frog   132 NWMLQTLNDEPEKPKVEEKVEEPAKVPELKQGLYELTAANFKEHIAEGNHFIKFFAPWC------ 190

  Fly   180 YRFGHSSEKEVLDKQGETDKIVLIRAPHLSNKFESSSIKFEGSSESDLSTFVKENFHGLVGHRTQ 244
               ||...                    |:..:|..:..|:.|:...::.......:||.   :.
 Frog   191 ---GHCKA--------------------LAPAWEQLAATFQDSNSIKIAKVDCTQHNGLC---SD 229

  Fly   245 DSVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDF 309
            :.|:.:...|.       ::...|...|...|.|...||:.             :.:|
 Frog   230 NQVRGYPTLLW-------FRNGEKVDQYKGKRDLDSLKEYA-------------ESQL------- 267

  Fly   310 VGDKPVVLARDEKNLKYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNF 374
               ||....::|:..:.|...:         |||.:|.|.:....||               .||
 Frog   268 ---KPAEEKKEEEQKEDATPPQ---------VEKPVAVESKVLSLSE---------------SNF 305

  Fly   375 DDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQD--EDVAIVKMDATA-NDVPPEFNVRG 436
            |..|...  .:.|:||||||||||.|.||:|:|::|...  .||.|.|:|.|| ..:...|:|||
 Frog   306 DQTVATG--VSFIKFYAPWCGHCKNLVPIWEDLSKKEFSGMSDVKIAKVDCTAERALCNRFSVRG 368

  Fly   437 FPTLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTEL 475
            :|||  |...|..|...:.|.|:::....::.:.:..||
 Frog   369 YPTL--LLFRAGEKIGEHEGARDLETLQNFVLRHSRDEL 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	121/477 (25%)
		PDI_a_PDIR	23..126	CDD:239295	41/114 (36%)
		PDI_b_ERp57	133..235	CDD:239367	14/101 (14%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	16/105 (15%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	40/104 (38%)
txndc5	NP_989186.1	PDI_a_ERp46	36..134	CDD:239303	38/99 (38%)
		PDI_a_ERp46	163..262	CDD:239303	19/137 (14%)
		PDI_a_ERp46	296..397	CDD:239303	42/119 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910