DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and pdia2

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001307463.1	Gene:	pdia2 / 394023	ZFINID:	ZDB-GENE-040426-705	Length:	555	Species:	Danio rerio

Alignment Length:	478	Identity:	149/478 - (31%)
Similarity:	247/478 - (51%)	Gaps:	38/478 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEA 85
            ::|||.|...:|...|.:::..||.|||||||||:.|:|.||:.|..:|:....::|||||..|.
Zfish    55 DKDVLILHSVNFDRALSENKYLLVEFYAPWCGHCRSLEPIYAEVAGQLKNASSEVRLAKVDAIEE 119

  Fly    86 GKETCSKYSVSGYPTLKIFRQD--EVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLD 148
             ||..|::||..:||||.|::.  :.:..:.|.|...||.:::.....|::..:..|...:..|:
Zfish   120 -KELASEFSVDSFPTLKFFKEGNRQNATTFFGKRTLKGIKRWLEKHTAPSATVLNDVKSAEALLE 183

  Fly   149 TKDTTLFGYFSDSDSKLAKIF----LKFADKNREKYRFGHSSEKEVLDK-QGETDKIVLIRAPHL 208
            ..:..:.|:|.|.:.:.||.|    |...|.|     ||.:|:.|:..| :.:||.:||.:
Zfish   184 ANEVLVVGFFKDLEGEKAKTFYDVTLIAVDVN-----FGITSDPELFKKYEVKTDSLVLFK---- 239

  Fly   209 SNKFESSSIKFEGSSESDLS-----TFVKENFHGLVGHRTQDSVKDFQNPLITAYYSVDYQKNPK 268
              ||:........|.|:.|.     :|:..|...||....:::.:...|..:..:..:.......
Zfish   240 --KFDERRADMPLSDETKLDKGEMISFIHSNSMRLVVPFNEENAEQIFNSKVRKHLLLFLNTTVD 302

  Fly   269 GTNYWRNRVLKVAKEFVGQINFAI--ASKDDFQHELNEYGYDFVGDKPVV-LARDEKNLKYALK- 329
            ..|.......:||.||..::.|..  .:.:...|.|..:... ..|.|.: |...|..:.||:.
Zfish   303 SQNALVEEFREVASEFKEKVIFITVDVTAEKVNHVLKYFSIS-EDDVPTIRLINTEDVVTYAMDG 366

  Fly   330 DEFSVENLQDFVEKLLANELEPYIKSEPIPESNDA-PVKVAVAKNFDDLVINNGKDTLIEFYAPW 393
            ...:.:.|:.|.:.:....::||:||:.|||..|. ||||.|.|||:::..:..|:..:||||||
Zfish   367 STINKDTLRTFCQGVFDGTVKPYLKSQEIPEDWDKNPVKVLVGKNFNEVAFDESKNVFVEFYAPW 431

  Fly   394 CGHCKKLSPIYEELAEKLQD-EDVAIVKMDATANDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGG 457
            ||||::|:|:::||.||.:| |::.|.|||||.||| .:..::||||:.:.|...:.|.|.|:|.
Zfish   432 CGHCQQLAPVWDELGEKYKDQENIIIAKMDATENDV-EDLTIQGFPTIKYFPAGTEKKIVDYDGN 495

  Fly   458 REVDDFLKY------IAKEATTE 474
            |:::.|.|:      :.||.:.|
Zfish   496 RDLETFSKFLDNGGVLPKEESKE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	149/476 (31%)
		PDI_a_PDIR	23..126	CDD:239295	43/104 (41%)
		PDI_b_ERp57	133..235	CDD:239367	26/111 (23%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	18/109 (17%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	48/108 (44%)
pdia2	NP_001307463.1	ER_PDI_fam	56..512	CDD:273457	146/469 (31%)
		PDI_a_family	65..161	CDD:239259	39/96 (41%)
		PDI_b_family	169..268	CDD:239279	26/109 (24%)
		PDI_b'_family	280..382	CDD:239280	17/102 (17%)
		PDI_a_PDI_a'_C	403..505	CDD:239293	48/102 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760