DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and Pdia5

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001014147.1	Gene:	Pdia5 / 360722	RGDID:	1359236	Length:	517	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	113/507 - (22%)
Similarity:	181/507 - (35%)	Gaps:	184/507 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QDVLEL-GDDDFATTLKQHE-TTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDD--------PP-- 74
            :||:.: .:.||...||:.| ..|:|||||||..|||:.|.:.|||..|:...        ||
  Rat   149 KDVVHIDSEKDFRRLLKKEEKPLLMMFYAPWCSMCKRIMPHFQKAATQVRGHTVLAGMNVYPPEF 213

  Fly    75 --IKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDY-NGPREASGIAKYMRAQVGPASKT 136
              ||              .:|:|.||||:..|.:......| |....|..|.::::....|..:.
  Rat   214 ENIK--------------EEYNVRGYPTICYFEKGRFLFQYENYGSTAEDIVEWLKNPQPPQPQV 264

  Fly   137 VRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQGETDKIV 201
            ..|.                 ::|....:..:    .|::.:::...|||            .:|
  Rat   265 PETP-----------------WADEGGSVYHL----TDEDFDQFVKEHSS------------VLV 296

  Fly   202 LIRAP------HLSNKFESSSIKFEGSSESD---------LSTFVKENFHGLVGHRTQDSVKDFQ 251
            :..||      .:..:|||::....|.:||.         ::..:.|.||
  Rat   297 MFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVDATINEALAERFH--------------- 346

  Fly   252 NPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFVGDKPVV 316
               |:|:.::.|.||                                            |::..|
  Rat   347 ---ISAFPTLKYFKN--------------------------------------------GEQQAV 364

  Fly   317 LARDEKNLKYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINN 381
            .|...|               :.|:|.:...|..|  ..||..|.....|...|..||.: .:..
  Rat   365 PALRTK---------------KKFIEWMQNPEAPP--PPEPTWEEQQTSVLHLVGDNFRE-TLKK 411

  Fly   382 GKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDE-DVAIVKMDATAN---DVPPEFNVRGFPTLFW 442
            .|.||:.||||||.||||:.|.:...|:..:|: .:|...:|...:   |:..:.:|:.:||..:
  Rat   412 KKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQESVKAYPTFHY 476

  Fly   443 LPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKGFD------RSGKPKKTE 488
                       |:.|:.|:   ||  :...||| ||.      |.|..|:.|
  Rat   477 -----------YHYGKLVE---KY--ESDRTEL-GFTSFIRTLREGDLKRLE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	108/489 (22%)
		PDI_a_PDIR	23..126	CDD:239295	38/117 (32%)
		PDI_b_ERp57	133..235	CDD:239367	16/116 (14%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	11/105 (10%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	30/105 (29%)
Pdia5	NP_001014147.1	PDI_b_PDIR_N	26..137	CDD:239365
		PDI_a_PDIR	150..254	CDD:239295	38/117 (32%)
		ER_PDI_fam	166..501	CDD:273457	103/478 (22%)
		PDI_a_PDIR	275..377	CDD:239295	27/194 (14%)
		PDI_a_PDIR	396..499	CDD:239295	36/120 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	514..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910