DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and Txndc11

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001121004.1	Gene:	Txndc11 / 302899	RGDID:	1307538	Length:	947	Species:	Rattus norvegicus

Alignment Length:	676	Identity:	132/676 - (19%)
Similarity:	218/676 - (32%)	Gaps:	248/676 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VLEL--GDDDFATTLKQ-HETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDC-TE 84
            ||:|  |..|:|..::| .|..::.|||||||.....:.|..:||..:.|.   :....|:| ..
  Rat   103 VLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQ---VLFVAVNCWWN 164

  Fly    85 AGKETCSKYSVSGY-PTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLD 148
            .||  |.|.....| |.:.::.:.....:|.||..|..|.|::|..:.|. ..:.:.:||..||.
  Rat   165 QGK--CRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPL-LYIPSQSELLDFLS 226

  Fly   149 TKDTTLFGYFSDSDS---------------------------------KLAKI------------ 168
            ..:..:.|||..|.|                                 .|||:
  Rat   227 NYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVITNKHLAKLVSLVHSGSVYLH 291

  Fly   169 --------------------FLKFADKNRE---KYRFGHSSEKEVLD---KQGET---------- 197
                                ..|:|.:|:|   ::...|..:..:|:   |:|..
  Rat   292 RHFNTSLVFPREVMNFTAENIYKWASENQETLFRWLQPHGGKSLLLNNELKKGPALFLFIPFDPL 356

  Fly   198 ----------------------------------------------------------------D 198
                                                                            :
  Rat   357 AERHPLLDEITEVALEYSNCRGDQVVERLLQHLRRAEAPVFQSLAPELQAPLPDAQLMAASPCCN 421

  Fly   199 KIVLIRAPHLSNKF-------------ESSSIK------FEGSSESDLSTFVKE-NFHGLVGHRT 243
            .:||.:.|.||...             ..||:.      ||.::..| |.::|| .|:.:|....
  Rat   422 TVVLPQGPALSRTHNVCELCVNQSVGTRPSSVSVPQCSFFEMAAALD-SFYLKEQTFYRVVSGSI 485

  Fly   244 QDSVKDFQNPLITAY-----YSVDYQKNPKGTNYWRNRVLKVAKEFVG-QINFAIASK------- 295
            :.|      ..:|:|     |:...:...:||..:......|   |.. .|.|:...|
  Rat   486 ECS------NFLTSYSPFSFYTACCRTISRGTASFSGSAQDV---FTAPAIEFSALEKSCEATAP 541

  Fly   296 DDFQH-ELNEYGYDFVGDKPVVL----ARDEKNLKYALKD--------------------EFSV- 334
            ....| |.|.|.:..||......    .|..|.|...|.|                    ||:.
  Rat   542 SSIPHIEENRYRFPEVGLSSTAFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSAPVKEFATI 606

  Fly   335 -------ENLQDFVEKLLANELEPYIKS-----EPI------PESNDAPVKVAVAKNFDDL---V 378
                   ..:.|..:.|:...||.:|::     .|:      .:|...|.:..:.:...|.   |
  Rat   607 VDVKEESHYILDPKQALVKLTLESFIQNFSVLYSPLKRHLTGSDSAQFPTQHLITEVTTDTFWEV 671

  Fly   379 INNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDEDVAIVKMDATANDVPPEFNVRGFPTLFWL 443
            ....:|.|:.:|..|||.|..|:.|:.:||..|.::...:.::|.:.||:|.||.|...||:.:.
  Rat   672 TLRKQDVLLLYYTQWCGFCPSLNHIFIQLARLLPEDTFTVARIDVSQNDLPWEFMVDRLPTVLFF 736

  Fly   444 PKDAKNKPVSYNGGREV--DDFLKYI 467
            |.:.|:..|.|.|...:  .:.|::|
  Rat   737 PCNRKDLSVKYPGDLPITLPNLLRFI 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	132/676 (20%)
		PDI_a_PDIR	23..126	CDD:239295	33/106 (31%)
		PDI_b_ERp57	133..235	CDD:239367	33/266 (12%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	26/151 (17%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	30/106 (28%)
Txndc11	NP_001121004.1	PDI_a_EFP1_N	93..205	CDD:239304	33/106 (31%)
		PDI_b_family	215..319	CDD:239279	14/103 (14%)
		Thioredoxin_6	254..396	CDD:290560	11/141 (8%)
		PDI_a_PDI_a'_C	660..762	CDD:239293	29/101 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900