DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and Erp44

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001008318.1	Gene:	Erp44 / 298066	RGDID:	1309176	Length:	406	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	108/470 - (22%)
Similarity:	175/470 - (37%)	Gaps:	148/470 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLGFIAISSGAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDP 73
            |||...:|.:....::..|..::....|...:..||.|||.||...:.|.|.:.:|::::|::.|
  Rat    16 LLLLVTSIFAPITAEIASLDSENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEYP 80

  Fly    74 ---PIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQD-EVSQDYNGPREASGIAKYMRAQVGPAS 134
               .:..|:||| :...:...:|.:|.|||||:||.. .:.::|.|.|....:|.|:|.|.....
  Rat    81 DKNQVVFARVDC-DQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSNPV 144

  Fly   135 KTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLK--------------FADKNR-EKYRFGH 184
            ..::::.|:.. ||.....:.|||...||...::|.:              |.|.:: |:|
  Rat   145 HEIQSLDEVTN-LDRSKRNIIGYFEQKDSDNYRVFERVASILHDDCAFLSAFGDLSKPERY---- 204

  Fly   185 SSEKEVLDKQGET---------------------DKIV-LIRAPHLSNKFESSSIKFEGSSESDL 227
            |.:..:....|.:                     ||.| |:|           .|.||...|
  Rat   205 SGDNLIYKPPGRSVPDMVYLGSMTNFDVTFNWIQDKCVPLVR-----------EITFENGEE--- 255

  Fly   228 STFVKENFHGLV-GHRTQD--SVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFV---G 286
              ..:|....|: .|..:|  |::.|||                          :||::.:   |
  Rat   256 --LTEEGLPFLILFHMKEDTESLEIFQN--------------------------EVARQLISEKG 292

  Fly   287 QINFAIASKDDFQHELNEYGYDFVGDKPVVLARDEKNLKYALKDEFSVENLQDFVEKLLANELEP 351
            .|||..|..|.|:|.|... .....|.||: |.|.....|.         ..||.:.|:..:|:.
  Rat   293 TINFLHADCDKFRHPLLHI-QKTPADCPVI-AIDSFRHMYV---------FGDFKDVLIPGKLKQ 346

  Fly   352 YIKSEPIPESNDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDEDV 416
            ::                    ||   :::|| ...||:     |    .|...:.|...||:||
  Rat   347 FV--------------------FD---LHSGK-LHREFH-----H----GPDPTDTAPGEQDQDV 378

  Fly   417 AIVKMDATANDVPPE 431
            |         ..|||
  Rat   379 A---------SSPPE 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	104/456 (23%)
		PDI_a_PDIR	23..126	CDD:239295	31/106 (29%)
		PDI_b_ERp57	133..235	CDD:239367	25/138 (18%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	25/111 (23%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	17/67 (25%)
Erp44	NP_001008318.1	PDI_a_ERp44	29..136	CDD:239294	31/107 (29%)
		PDI_b_ERp44	144..234	CDD:239368	15/94 (16%)
		Thioredoxin_6	167..350	CDD:290560	48/259 (19%)
		PDI_b'_ERp44	245..355	CDD:239370	36/185 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910