DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and Tmx4

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001093999.1	Gene:	Tmx4 / 296182	RGDID:	1305146	Length:	336	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	81/380 - (21%)
Similarity:	123/380 - (32%)	Gaps:	130/380 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLLGFIAISS----GAEQDVLELGDDDFATTLKQHETTLVM-------FYAPWCGHCKRLKPE- 60
            |.|..::|.::    |.||..|. .::.....:.....||||       ||||||..|::...|
  Rat     9 VFLAAWLAAAAAEAEGLEQAALP-AEESRVQPMTASNWTLVMEGEWMLKFYAPWCPSCQQTDSEW 72

  Fly    61 --YAKAAEIVKDDDPPIKLAKVD-CTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGI 122
              :||..|.::     |.:.||| ..|.|  ...::.|:..|.. ...:|.:.:.|.||.....:
  Rat    73 ETFAKNGETLQ-----ISVGKVDVIQEPG--LSGRFFVTTLPAF-FHAKDGIFRRYRGPGIYEDL 129

  Fly   123 AKY-----------MRAQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKN 176
            ..|           :.....|||.|:..:|              |.||.|    .||:
  Rat   130 QNYILEKKWQSVEPLTGWKSPASLTMSGMA--------------GLFSIS----GKIW------- 169

  Fly   177 REKYRFGHSSEKEVLDKQGETDKIVLIRAPHLSNKFE--------SSSIKFEGSSESDLSTFVKE 233
                                          ||.|.|.        .|.:.|.      ::|.|..
  Rat   170 ------------------------------HLHNYFTVTLGIPAWCSYVFFV------IATLVFG 198

  Fly   234 NFHGLVGHRTQDSVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVG--QINFAIASKD 296
            .|.||:               :.......|...|:.::. |:...:.::|..|  |:..|...||
  Rat   199 LFMGLI---------------LVVISECFYVPLPRASSE-RSEQEQRSEEAQGAEQLQDAEEEKD 247

  Fly   297 DFQHELN--------EYGYDFVGDKPVVLARDEKNLKYALKDEFSVENLQDFVEK 343
            |...|.|        |...|...|..|....:|.||...:.:|.|..|.|..|::
  Rat   248 DSNEEENKDSLVDDEEEKEDLGDDDEVEEDEEEDNLAGIMDEEKSDSNEQGVVKE 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	75/361 (21%)
		PDI_a_PDIR	23..126	CDD:239295	29/124 (23%)
		PDI_b_ERp57	133..235	CDD:239367	18/109 (17%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	24/115 (21%)
		PDI_a_PDI_a'_C	365..467	CDD:239293
Tmx4	NP_001093999.1	Thioredoxin_like	35..135	CDD:294274	28/107 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840