DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and Pdia3

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_059015.2	Gene:	Pdia3 / 29468	RGDID:	68430	Length:	510	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	234/503 - (46%)
Similarity:	318/503 - (63%)	Gaps:	30/503 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LAGVLLLGFIAISSGA----EQDVLELGDDDFATTLKQHETT---LVMFYAPWCGHCKRLKPEYA 62
            |.||.||...|:.:.|    ..|||||.|::|.:.:....:.   ||.|:||||||||||.|||.
  Rat     9 LPGVALLLASALLASALLASASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYE 73

  Fly    63 KAAEIVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMR 127
            .||..:|...|   ||||||| |...||:||.|||||||||||..|.:..|:|||.|.||..:::
  Rat    74 AAATRLKGIVP---LAKVDCT-ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLK 134

  Fly   128 AQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVL- 191
            .|.||||..:||..|.|||:..||.::.|:|.|..|.....|||.|...|:.|||.|::.:.::
  Rat   135 KQAGPASVPLRTEDEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVK 199

  Fly   192 --DKQGETDKIVLIRAPHLSNKFESSSIKF--EGSSESDLSTFVKENFHGLVGHRTQDSVKDF-- 250
              |..||  .|.:.|..||:||||...:.:  :..:...:..|::|:..||..|.|:|: ||.
  Rat   200 EYDDNGE--GITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDN-KDLIQ 261

  Fly   251 QNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVG---QINFAIASKDDFQHELNEYGYD-FVG 311
            ...|:||||.|||:||.||:|||||||:.|||.|:.   ::|||:||:..|.|||:::|.: ..|
  Rat   262 GKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTG 326

  Fly   312 DKPVVLARDEKNLKYALKDEFSVEN--LQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNF 374
            :.|||..|..|..|:.:::|||.:.  |:.|:::.....|:.|:|||||||:|:.||||.||::|
  Rat   327 EIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVKVVVAESF 391

  Fly   375 DDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKL-QDEDVAIVKMDATANDVPPEFNVRGFP 438
            ||:|....||.|||||||||||||.|.|.|:||.||| :|.::.|.||||||||||..:.|:|||
  Rat   392 DDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFP 456

  Fly   439 TLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKGFDRSGKPKK 486
            |:::.|.:.|..|..|.||||::||:.|:.:|||.  ....:..||||
  Rat   457 TIYFSPANKKLTPKKYEGGRELNDFISYLQREATN--PPIIQEEKPKK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	223/472 (47%)
		PDI_a_PDIR	23..126	CDD:239295	58/105 (55%)
		PDI_b_ERp57	133..235	CDD:239367	36/106 (34%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	50/113 (44%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	60/102 (59%)
Pdia3	NP_059015.2	ER_PDI_fam	31..492	CDD:273457	223/469 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..510		6/16 (38%)
		Prevents secretion from ER	507..510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350319
Domainoid	1	1.000	132	1.000	Domainoid score	I4987
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68454
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1731
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		oto96850
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	LDO	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770