DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and Pdilt

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	XP_038963539.1	Gene:	Pdilt / 293544	RGDID:	1307822	Length:	615	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	136/562 - (24%)
Similarity:	234/562 - (41%)	Gaps:	106/562 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMWR----LAGVL--LLGFIAISSG----------AEQDVLELGDDDFATTLKQHETTLVMFYAP 49
            ::|.    ||..|  :||...:.:|          .:.:::.|.......||.:....:|:|:.|
  Rat    28 LLWTPLLLLAACLSEVLGSPEMDTGINISQPLHILEDHNLMVLTPAGLTQTLNETRFLMVIFHNP 92

  Fly    50 WCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYN 114
            .....::|..|..|||||.......:...|||.| ...|...::.::..|.||:|        |.
  Rat    93 TLKQSRKLAKELGKAAEIFGKGKNGLGFGKVDIT-METELKQEFDITHAPELKLF--------YE 148

  Fly   115 GPR----------EASGIAKYMRAQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIF 169
            |.|          |::.:..::|.|:...:.......|:..|:.::...:.|:|.|.:.::|::|
  Rat   149 GNRLEPISCKDVVESTALVVWLRRQISKKALLFNNSNEVADFVKSRPLVIVGFFQDLEEEVAELF 213

  Fly   170 LKFADKNREKYRFGHSSEKE-------VLD-----KQGETDKIVLIRAPHLSNKFESSSIKFEGS 222
            .. ..|:..:..||....|.       :||     |:|.     :::...|.|         :.:
  Rat   214 YD-TIKDFPELTFGAIQIKNSFGRFHVILDSVLVFKKGR-----VVKRQELIN---------DST 263

  Fly   223 SESDLSTFVKENFHGLVGHRTQDSVKDF---QNPLITAYYSVDYQKNPKGT--NYWRNRVLKVAK 282
            ::..|:..:|:...|.|.....:: ||.   .|.|......:.....|..|  .::|    :::|
  Rat   264 NKDYLNQVIKQQLTGFVIEFNPEN-KDLIYEMNILNHMLLFISKNSEPYSTIIRHYR----QISK 323

  Fly   283 EFVGQINFAIASKDDFQHE-LNEY-GYDFVGDKPVVLARDEKNLKYAL-KDEFSVENLQDFVEKL 344
            ||..:|.|.:.:.|:.::: :.|| ....|....|.:.....:.:|.: .|..:.|:|:.|....
  Rat   324 EFQNKILFVLVNSDEPKNKRIFEYFQISRVNVPSVQILNLSSDARYKMPTDNITFESLKKFCNSF 388

  Fly   345 LANELEPYIKSEPIPESND-APVKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELA 408
            |:...:.:..||.||:..| .|||..|.|||:.:|.:..||..:.|||||...|:.|.|:.|||.
  Rat   389 LSRTAKKHKSSEEIPKYWDQEPVKKLVGKNFNVVVFDKEKDVFVMFYAPWSEKCRVLLPLLEELG 453

  Fly   409 EKLQDED-VAIVKMDATANDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGGR-------------- 458
            .|.|:.. |.|.|:|.||||:... |...:|.....|.|:: :.|.|.|..
  Rat   454 IKYQNHSTVIIAKIDITANDIQLA-NPEQYPFFRLFPTDSQ-EAVMYKGEHTMKGFCDFLESHVK 516

  Fly   459 ---EVDDFLKYI-----AKE---ATTELKGFDRSGKPKKTEL 489
               |.||.|.||     |:|   |..|::..|:  .|:|..|
  Rat   517 VRIEEDDELLYIEQNEVAEEEVLAEPEMQHIDK--LPEKPPL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	125/512 (24%)
		PDI_a_PDIR	23..126	CDD:239295	26/112 (23%)
		PDI_b_ERp57	133..235	CDD:239367	19/113 (17%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	23/113 (20%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	42/119 (35%)
Pdilt	XP_038963539.1	ER_PDI_fam	69..523	CDD:273457	116/484 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350318
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750